Recombinant human growth hormone promotes wound angiogenesis in burned
mice through the ERK signaling pathway

Yang Shao,; Mei Han,; Guoyue Chen,; Guodong Song,

doi:10.14715/cmb/2024.70.5.36

Cell Mol Biol (Noisy-le-grand)

2024

DOI: 10.14715/cmb/2024.70.5.36

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Recombinant human growth hormone promotes wound angiogenesis in burned mice through the ERK signaling pathway

Yang Shao,

Mei Han,

Guoyue Chen

et al.

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Hormonal interventions in skin wounds – a mini review

Li,

Ma,

Tan

et al. 2024

Mol Med

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The ability to heal from wounds is perhaps the most important biological function that ensures our survival and perpetuation. Cutaneous wound healing typically consists of four characteristic stages, namely hemostasis, inflammation, proliferation, and remodeling, which are carefully carried out by coordinated actions of various cells, cytokines, and hormones. Incoordination of these steps may impede complete and efficient reconstruction and functional recovery of wounds or even lead to worsened outcomes. Hormones, as powerful modulators of organ functions, participate in multiple steps of the wound healing process and play a pivotal role by choreographing the complex interplay of cellular and molecular events. Leveraging the regulatory effects of hormones to enhance the healing process, hormonal therapy has emerged as a promising approach in the clinical treatment of wounds. Current research has focused on determination of the optimal dosages, delivery methods, and combinations of hormonal therapies to maximize their therapeutic benefits while minimizing potential side effects. This review highlights the molecular mechanisms, clinical benefits and side effects of the most commonly used hormones in clinical treatment of wounds.

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Hormonal interventions in skin wounds – a mini review

Li,

Ma,

Tan

et al. 2024

Mol Med

View full text Add to dashboard Cite

show abstract

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Recombinant human growth hormone promotes wound angiogenesis in burned mice through the ERK signaling pathway

Cited by 1 publication

References 18 publications

Hormonal interventions in skin wounds – a mini review

Hormonal interventions in skin wounds – a mini review

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