2024
DOI: 10.1002/adhm.202302970
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Recombinant Human Keratinocyte Growth Factor Ameliorates Cancer Treatment‐Induced Oral Mucositis on a Chip

Khanh L. Ly,
May Rajtboriraks,
Ahmed Elgerbi
et al.

Abstract: Oral mucositis (OM) is a severe complication of cancer therapies caused by off‐target cytotoxicity. Palifermin, which is recombinant human keratinocyte growth factor (KGF), is currently the only mitigating treatment available to a subset of OM patients. Determining the cell and molecular mechanisms of cancer treatment‐induced OM and the anti‐mucositis effects of KGF will aid in identifying effective future treatments. This study evaluates a previously developed oral mucositis on a chip (OM‐OC) as a screening p… Show more

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