Recombinant human β-defensin130 inhibited the growth of foodborne bacteria through membrane disruption and exerted anti-inflammatory activity

Dong, Bin; Lin, Yanjun; Su, Zhiwei; Sun, Chunlong; Wang, Jun; Fu, Shijun; Du, Wei; Wu, Tao

doi:10.1007/s10068-022-01087-y

Cited by 2 publications

(2 citation statements)

References 57 publications

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“…As mentioned above, most studies to date have focused on inflammation induced by LPS from Gram-negative bacteria. For example, CAP11, studied by Shibusawa K et al in 2009 [ 16 ], β-defensin 2, studied by Huang C et al in 2017 and 2022 [ 26 , 27 ], and hBD130, studied by D et al in 2022 [ 29 ], all achieved the goal of suppressing inflammation by inhibiting LPS. However, few studies have investigated the anti-inflammatory role of AMPs in immune cells following stimulation with LTA from Gram-positive bacteria, fungi, and viruses, as well as by physical and chemical factors.…”

Section: Discussionmentioning

confidence: 99%

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The Contribution of Antimicrobial Peptides to Immune Cell Function: A Review of Recent Advances

Li,

Niu,

Wang

et al. 2023

Pharmaceutics

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The development of novel antimicrobial agents to replace antibiotics has become urgent due to the emergence of multidrug-resistant microorganisms. Antimicrobial peptides (AMPs), widely distributed in all kingdoms of life, present strong antimicrobial activity against a variety of bacteria, fungi, parasites, and viruses. The potential of AMPs as new alternatives to antibiotics has gradually attracted considerable interest. In addition, AMPs exhibit strong anticancer potential as well as anti-inflammatory and immunomodulatory activity. Many studies have provided evidence that AMPs can recruit and activate immune cells, controlling inflammation. This review highlights the scientific literature focusing on evidence for the anti-inflammatory mechanisms of different AMPs in immune cells, including macrophages, monocytes, lymphocytes, mast cells, dendritic cells, neutrophils, and eosinophils. A variety of immunomodulatory characteristics, including the abilities to activate and differentiate immune cells, change the content and expression of inflammatory mediators, and regulate specific cellular functions and inflammation-related signaling pathways, are summarized and discussed in detail. This comprehensive review contributes to a better understanding of the role of AMPs in the regulation of the immune system and provides a reference for the use of AMPs as novel anti-inflammatory drugs for the treatment of various inflammatory diseases.

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Section: Discussionmentioning

confidence: 99%

“…Furthermore, β-defensin DEFB123 inhibits the release of TNF-α and the LPS-induced activation of the MAPK signaling pathway in RAW264.7 cells [ 28 ]. hBD130 reduces LPS-induced generation of NO, IL-1β, IL-6, and TNF-α in mouse macrophages [ 29 ].…”

Section: Regulatory Effect Of Amps On Macrophagesmentioning

confidence: 99%

The Contribution of Antimicrobial Peptides to Immune Cell Function: A Review of Recent Advances

Li,

Niu,

Wang

et al. 2023

Pharmaceutics

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Inhibitory Effects of Antimicrobial Peptides from Lactobacillus casei HZ1 on Lipopolysaccharide-Induced RAW264.7 Macrophages Inflammation

Jin

2022

Int J Pept Res Ther

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Recombinant human β-defensin130 inhibited the growth of foodborne bacteria through membrane disruption and exerted anti-inflammatory activity

Cited by 2 publications

References 57 publications

The Contribution of Antimicrobial Peptides to Immune Cell Function: A Review of Recent Advances

The Contribution of Antimicrobial Peptides to Immune Cell Function: A Review of Recent Advances

Inhibitory Effects of Antimicrobial Peptides from Lactobacillus casei HZ1 on Lipopolysaccharide-Induced RAW264.7 Macrophages Inflammation

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