Recombinant Porcine Leptin Reduces Feed Intake and Stimulates Growth Hormone Secretion in Swine

Barb, C. R.; Yan, Xiaolang; Azain, M.J.; Kraeling, Robert R.; Rampacek, George B.; Ramsay, Timothy

doi:10.1016/s0739-7240(97)00064-7

Cited by 185 publications

(124 citation statements)

References 30 publications

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“…The observation that leptin inhibits cortisol synthesis by adrenal cells (Bornstein et al, 1997;Pralong et al, 1998) is supported by the negative correlation observed in this experiment between plasma circulating leptin and cortisol (P , 0.01; r 5 20.74). In contrast, the observation that leptin increases GH plasma concentration (Barb et al, 1998) is supported by the positive correlation between plasma levels of the two hormones observed in this experiment (P , 0.01; r 5 0.81). To our knowledge, this study is the first to demonstrate that circulating leptin levels reflect nutrition-induced differences in body fatness within a defined population of pigs.…”

supporting

confidence: 46%

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Nutrition-induced differences in body composition, compensatory growth and endocrine status in growing pigs ,

Martínez-Ramírez

Jeaurond

Lange

2009

Animal

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In this experiment, we assessed the effect of amino acid (AA) intake restriction in entire male Yorkshire pigs between 15 and 38 kg BW (restriction phase) on BW gain, body composition and plasma levels of blood urea nitrogen (BUN), cortisol, insulinlike growth factor I (IGF-I), growth hormone (GH) and leptin during the subsequent re-alimentation phase. During the restriction phase, 36 pigs were allotted to one of two dietary treatments: adequate AA intake (control) or AA-limiting diets (AA-30%). Thereafter, pigs were fed common non-limiting diets up to 110 kg BW. Throughout the experiment, pigs were scale-fed at 90% of the estimated voluntary daily digestible energy intake. At the end of the restriction phase, pigs on AA-30% had lesser BW gain (650 v. 784 g/day; P , 0.001), loin area (LA; 12.2 v. 14.2 cm 2 ; P , 0.001), BUN (4.6 v. 6.3 mg/dl; P , 0.02), lesser plasma levels of IGF-I (440 v. 640 ng/m; P , 0.001) and cortisol (8.2 v. 19.2 mg/dl; P , 0.001), greater backfat thickness (BF; 7.56 v. 6.56 mm; P , 0.02), and greater plasma levels of leptin (2.7 v. 1.8 ng/ml; P 5 0.027) and GH (3.3 v. 2.0 ng/ml; P 5 0.05) than pigs on control. During the re-alimentation phase, previously restricted pigs showed full compensatory growth (CG) in terms of BW gain (1170 v. 1077 g/day; P , 0.002), whole-body protein deposition (Pd) (179 v. 163 g/day; P , 0.001) as well as physical and chemical body composition (whole-body lipid to body protein mass ratio, LB/PB; 1.14 v. 1.15; P . 0.10). Besides GH at 45 kg BW (4.2 v. 2.4 ng/ml; P 5 0.066), there were no effects of previous AA intake restriction on leptin, IGF-I and BUN during the re-alimentation phase ( P . 0.10). Plasma cortisol and IGF-I levels may act as an indicator of AA-induced restriction in Pd in growing pigs. Plasma BUN level does not appear as a sensitive indicator for compensatory Pd. Plasma leptin and GH levels allow for the involvement of the brain in controlling chemical body composition. Full CG was observed during the energydependent phase of Pd in growing pigs and might be driven by a target LB/PB, possibly mediated via plasma leptin, IGF-I and GH levels.

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supporting

confidence: 46%

“…It has been reported that leptin fulfills the role of adipostat, a sensor of body adiposity (Barb et al, 1998;Houseknecht et al, 1998). The role of adipostat is based on the strong association between leptin gene expression, circulating leptin levels, and body fat content across animals of different genotypes (Frederich et al, 1995;McDougald et al, 1995).…”

mentioning

confidence: 99%

Nutrition-induced differences in body composition, compensatory growth and endocrine status in growing pigs ,

Martínez-Ramírez

Jeaurond

Lange

2009

Animal

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“…Thereby, it is difficult to draw a clear-cut picture on the effects of exogenous leptin. Single injection of high-dose leptin (intra-cerebro-ventricular or in the carotid artery) increases GH secretion and decreases food intake (Barb et al, 1998). It also induces hypoglycaemia, hypoinsulinaemia and an increased concentration of non-esterified fatty acids (NEFA; Ramsay et al, 2004).…”

Section: Leptinmentioning

confidence: 99%

Growth and development of adipose tissue and gut and related endocrine status during early growth in the pig: impact of low birth weight

Morise

Louveau

Huërou‐Luron

2008

Animal

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With genetic selection, the increase in litter size has led to higher variation in within-litter birth weights in pigs. This has been associated with a reduction in mean birth weights and a rise in the proportion of piglets weighing less than 1 kg at birth. Low birth weight pigs exhibit lower postnatal growth rates and feed efficiency, which may be explained by an inadequate digestion and/or nutrient use as a consequence of prenatal undernutrition. It is now documented that there is a relationship between birth weight and subsequent pattern of growth and development of tissues and organs. During the neonatal period, the rapid somatic growth is accompanied by tremendous anatomical, physiological and chemical composition changes. The present review focuses primarily on the influence of low birth weight on adipose tissue and the gastrointestinal tract growth and development during the suckling period. The importance of the somatotropic axis, insulin, thyroid hormones, glucocorticoids, epidermal growth factor and leptin in the regulation of these developmental processes is also considered.

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“…Plasma leptin levels in cattle and sheep increase linearly with increased body fat mass and with increased energy balance [2,3,6]. Systemic or central administration of leptin reduces feed intake in rodents, chickens, pigs, and sheep [1,13,15,24] and while data from livestock species remains sparse, leptin appears to be an important component of a feedback loop involving key metabolic regulators including insulin, glucocorticoids and the sympathetic nervous system [16]. Finally, in vitro studies suggest that leptin can directly modulate energy metabolism in peripheral tissues and may antagonize insulin activities in adipose [21] and muscle [22].…”

Section: Introductionmentioning

confidence: 99%

Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels

et al. 2002

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-Previously, we have shown that alleles of the BM1500 microsatellite, located 3.6 kb downstream of the leptin gene in cattle, were associated with carcass fat measures in a population of 154 unrelated beef bulls. Subsequently, a cytosine (C) to thymine (T) transition that encoded an amino acid change of an arginine to a cysteine was identified in exon 2 of the leptin gene. A PCR-RFLP was designed and allele frequencies in four beef breeds were correlated with levels of carcass fat. The T allele was associated with fatter carcasses and the C allele with leaner carcasses. The frequencies of the SNP alleles among breeds indicated that British breeds have a higher frequency of the T allele whereas the continental breeds have a higher occurrence of the C allele. A ribonuclease protection assay was developed to quantify leptin mRNA in a separate group of animals selected by genotype. Animals homozygous for thymine expressed higher levels of leptin mRNA. This may suggest that the T allele, which adds an extra cysteine to the protein, imparts a partial loss of biological function and hence could be the causative mutation.leptin / cattle / obese / fat / marbling

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Recombinant Porcine Leptin Reduces Feed Intake and Stimulates Growth Hormone Secretion in Swine

Cited by 185 publications

References 30 publications

Nutrition-induced differences in body composition, compensatory growth and endocrine status in growing pigs ,

Nutrition-induced differences in body composition, compensatory growth and endocrine status in growing pigs ,

Growth and development of adipose tissue and gut and related endocrine status during early growth in the pig: impact of low birth weight

Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels

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