“…As the AA sequence of CbGH5 homologues is highly conserved in Chryseobacterium genus, they might potentially be interesting objects for mining cellulase or bifunctional cellulase–xylanase candidates. Bifunctional cellulase–xylanase activities were previously reported in GH7 (Nakazawa et al ., ; Karnaouri et al ., ; Pellegrini et al ., ), GH10 (Ding et al ., ; Hess et al ., ) and GH61 (Jagtap et al ., ) as well as in GH5_2 (Ghatge et al ., ), GH5_4 (Chang et al ., ; Hess et al ., ; Rashamuse et al ., ; Cheng et al ., ; Rattu et al ., ) and GH5_25 (Yuan et al ., ) (Table ), while CbGH5 is the first example in GH5_46. To date, CbGH5 and a metagenome‐derived protein 421339_68070/TW‐2 (GenBank accession number: ) (Hess et al ., ) are the only two glycoside hydrolases of GH5_46 that have been characterized.…”