Recomendaciones SEPAR de diagnóstico y tratamiento del cáncer de pulmón de células no pequeñas

Álvarez, Felipe Villar; Trueba, Ignacio Muguruza; Sanchis, José Belda; López-Rodó, Laureano Molins; Suárez, José P.; Escuín, Julio Sánchez de Cos; Barreiro, Esther; Pintado, M. Henar Borrego; Vicente, Carlos Disdier; Aldeyturriaga, Javier Flandes; Garcı́a, Pablo Gámez; Garrido, Pilar; Atance, Pablo León; Elena, José Miguel Izquierdo; Novoa, Nuria; Andrés, Juan José Rivas de; Crespo, Iñigo.; Velázquez, Ángel Salvatierra; Maceiras, Luís M. Seijo; Reina, Segismundo Solano; Bujanda, Luís; Martínez, Régulo José Ávila; Orive, José Ignacio de Granda; Martínez, Eva de Higes; Gude, V. Díaz Hellín; Flor, Raúl Embún; Gilart, Jorge L. Freixinet; Jiménez, María Dolores García; Alarza, Fátima Hermoso; Sarmiento, Samuel; Martínez, Antonio Francisco Honguero; Ruiz, Carlos A. Jiménez; Sanz, Iker López; Alba, Andrea Mariscal de; Vallina, Primitivo Martínez; Muñoz, Patricia Menal; Pérez, Laura Mezquita; Garcia, Maria Eugenia Olmedo; Rombolá, Carlos A.; Arregui, Íñigo San Miguel; Gutiérrez, María del Valle Somiedo; Ramírez, Ana Isabel Triviño; Reyes, Joan Carles Trujillo; Vallejo, Carmen; Lozano, Paz Vaquero; Varela, Gonzálo; Zulueta, Javier

doi:10.1016/s0300-2896(16)30198-3

Cited by 24 publications

(14 citation statements)

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“…On the other hand, there is evidence to suggest that the risk of developing LC and dying from it is greater in patients with GOLD I-II, while patients with GOLD III-IV die more from COPD itself. 40 …”

Section: Discussionmentioning

confidence: 99%

Influence of the type of emphysema in the relationship between COPD and lung cancer

Mouronte-Roibás

Fernández-Villar

Ruano-Raviña

et al. 2018

COPD

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IntroductionThere are no studies analyzing the relationship between emphysema and lung cancer (LC). With this aim and in order to make some comparisons between different clinical variables, we carried out the present study.MethodsThis is a case–control study, patients with COPD and LC being the cases and subjects with stable COPD being the controls. Clinical and functional parameters, as well as the existence of radiological emphysema, were evaluated in a qualitative and quantitative way, using a radiological density of −950 Hounsfield units as a cutoff point in the images. The existence of several different types of emphysema (centrilobular, paraseptal, panacinar, or bullae) was analyzed, allowing patients to have more than one simultaneously. The extent to which lobes were involved was evaluated and the extension of emphysema was graduated for each type and location, following a quantitative scale. Differences between cases and controls were compared by using bivariate and multivariate analyzes with results expressed as OR and 95% CI.ResultsWe included 169 cases and 74 controls, 84% men with a FEV1 (%) of 61.7±18.5, with 90.1% non-exacerbators. Most of them (50%) were active smokers and 47.2% were ex-smokers. Emphysema was found in 80.2% of the subjects, the most frequent type being centrilobular (34.4%). The only significantly different factor was the presence of paraseptal emphysema (alone or combined; OR =2.2 [95% CI =1.1–4.3, P = 0.03]), with adenocarcinoma being significantly more frequent in paraseptal emphysema with respect to other types (67.2% vs 32.8%, P =0.03).ConclusionPatients with COPD and paraseptal emphysema could be a risk group for the development of LC, especially adenocarcinoma subtype.

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Section: Discussionmentioning

confidence: 99%

Influence of the type of emphysema in the relationship between COPD and lung cancer

Mouronte-Roibás

Fernández-Villar

Ruano-Raviña

et al. 2018

COPD

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“…Muscle mass loss and wasting are characteristic features of patients with chronic conditions such as chronic heart failure, diabetes, renal failure, chronic obstructive pulmonary disease (COPD), cancer, and critical illness ( Alvarez et al, 2016 ; Barreiro et al, 2015 ; Barreiro, 2017 ; Diaz, Ospina-Tascon & Salazar, 2014 ; Evans et al, 2008 ; Fearon et al, 2011 ; Villar et al, 2016 ; Von & Anker, 2010 ) Cachexia is characterized by severe body weight and muscle loss together with alterations in metabolic parameters. Patients with cachexia experience severe muscle weakness, which has been consistently demonstrated to predict morbidity and mortality ( Barreiro et al, 2015 ; Evans et al, 2008 ; Fearon et al, 2011 ; Mador, Bozkanat & Kufel, 2003 ; Marquis et al, 2002 ; Patel et al, 2014 ; Seymour et al, 2010 ; Swallow et al, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Formoterol attenuates increased oxidative stress and myosin protein loss in respiratory and limb muscles of cancer cachectic rats

Salazar‐Degracia

Busquets

Argilés

et al. 2017

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Muscle mass loss and wasting are characteristic features of patients with chronic conditions including cancer. Therapeutic options are still scarce. We hypothesized that cachexia-induced muscle oxidative stress may be attenuated in response to treatment with beta2-adrenoceptor-selective agonist formoterol in rats. In diaphragm and gastrocnemius of tumor-bearing rats (108 AH-130 Yoshida ascites hepatoma cells inoculated intraperitoneally) with and without treatment with formoterol (0.3 mg/kg body weight/day for seven days, daily subcutaneous injection), redox balance (protein oxidation and nitration and antioxidants) and muscle proteins (1-dimensional immunoblots), carbonylated proteins (2-dimensional immunoblots), inflammatory cells (immunohistochemistry), and mitochondrial respiratory chain (MRC) complex activities were explored. In the gastrocnemius, but not the diaphragm, of cancer cachectic rats compared to the controls, protein oxidation and nitration levels were increased, several functional and structural proteins were carbonylated, and in both study muscles, myosin content was reduced, inflammatory cell counts were greater, while no significant differences were seen in MRC complex activities (I, II, and IV). Treatment of cachectic rats with formoterol attenuated all the events in both respiratory and limb muscles. In this in vivo model of cancer-cachectic rats, the diaphragm is more resistant to oxidative stress. Formoterol treatment attenuated the rise in oxidative stress in the limb muscles, inflammatory cell infiltration, and the loss of myosin content seen in both study muscles, whereas no effects were observed in the MRC complex activities. These findings have therapeutic implications as they demonstrate beneficial effects of the beta2 agonist through decreased protein oxidation and inflammation in cachectic muscles, especially the gastrocnemius.

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“…Su aparición representa un estadio avanzado de la enfermedad y mal pronóstico, y suele conllevar una elevada carga sintomática con el deterioro de la calidad de vida de los pacientes (1). Entre las diferentes opciones del manejo paliativo del DPM, el catéter pleural tunelizado permanente representa una alternativa válida en determinados casos seleccionados (2,3).…”

Section: Introductionunclassified

Manejo domiciliario del catéter pleural tunelizado permanente: A propósito de un caso

2020

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El derrame pleural maligno representa una entidad frecuente en pacientes con enfermedades neoplásicas. Su aparición representa un estadio avanzado de la enfermedad e indica mal pronóstico, y puede conllevar una elevada carga sintomática con el deterioro de la calidad de vida. Aunque su manejo debe individualizarse, en determinados casos, la utilización de catéteres pleurales tunelizados permanentes puede ser una alternativa segura y eficaz para intentar alcanzar un adecuado control de los síntomas.Presentamos el caso de una paciente diagnosticada en nuestro departamento de un mesotelioma pleural maligno con derrame pleural recidivante, a la que se le colocó un catéter pleural tunelizado puesto que los intentos previos de pleurodesis habían fracasado. Describimos el procedimiento, así como el manejo domiciliario. En este caso, se optó por un abordaje integral con apoyo domiciliario de la Unidad de Hospitalización a Domicilio de nuestro hospital.En definitiva, el catéter pleural permanente tunelizado representa una alternativa eficaz y segura en el manejo ambulatorio de los pacientes con derrame pleural maligno recidivante y sintomático. Este sistema permite la extracción de líquido pleural en el domicilio del paciente y alcanzar un mayor control de los síntomas respiratorios y una mayor calidad de vida en este grupo de pacientes.

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Recomendaciones SEPAR de diagnóstico y tratamiento del cáncer de pulmón de células no pequeñas

Cited by 24 publications

References 0 publications

Influence of the type of emphysema in the relationship between COPD and lung cancer

Influence of the type of emphysema in the relationship between COPD and lung cancer

Formoterol attenuates increased oxidative stress and myosin protein loss in respiratory and limb muscles of cancer cachectic rats

Manejo domiciliario del catéter pleural tunelizado permanente: A propósito de un caso

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