While the benefits of FAIR principles -findable, accessible, interoperable, reusable -and Open Data seem clear to most scientists, significant hurdles need to be overcome to make scientific databases useful and sustainable. The difficulties with incentivizing the community to share data, as encountered by the recently launched Open Membrane Database (OMD), can be used as a starting point to fuel the debate on the power and pitfalls of FAIR and Open Data practices.Science progresses through the acquisition, accumulation and dissemination of knowledge, which in turn is generated by gathering, curating and interpreting data. Data has been generated at increased speed and volume over the past decades 1 , and are often the foundation of scientific publications. Yet, in the current status quo, the data are very rarely findable, accessible, interoperable, reusable, and open (FAIR/O), neither during the article reviewing process nor after the article has been published 2 . Verifying, replicating, and reusing data, all processes fundamental to science, is therefore often unachievable. This significantly limits enhanced understanding of science, rational and data-driven research, and machine-actionability 2,3 . Aside from the lack of accessibility, there is often a lack of standardized procedures to collect data, for example, to manufacture and test materials, making comparison and benchmarking unreliable 4 .Databases, both general and domain-specific, that meet the FAIR/O principles could provide a solution to the limitations of the current status quo (Table 1). The Open Membrane Database (OMD), launched in August 2021, is such a database that was designed based on FAIR/O data management in the field of water purification membranes 5 . It was developed by researchers, for researchers, as an open-source archive of the performance and physicochemical properties of reverse osmosis desalination membranes. The protocols by which the data are gathered are openly accessible and all datapoints have a unique and persistent identifier. The OMD falls under a creative commons license that allows users to copy and redistribute the data in any medium or format, and to remix, transform, and build upon the material (that is, CC BY-NC 4.0). This domainspecific database also contains interactive plots and filters to explore and manipulate the dataset in various ways, and it has the option to export the data as a plain text file. The OMD therefore meets the FAIR/O guidelines and can be used without any restrictions and is free of charge.