“…Early reports indicate that patients with COVID-19 do not show airway mucus hypersecretion, however, patients with specific comorbidities (e.g., COPD, cystic fibrosis, neuromuscular disease) might actually need respiratory support due to airway secretion retention or ineffective cough. In case of clinical signs for presence of airway secretion (by hearing, feeling, or chest x-ray), different techniques and devices can be applied to mobilization or evacuation ( 76 ). In hypersecretive patients, the use of continuous or temporary positive expiratory pressure device with or without oscillation (PEP, TPEP, OPEP), should be considered, alone or in combination with lung expansion strategies, to enhance lung volume recruitment, to better control the expiration flow and to facilitate peripheral and proximal mucus mobilization.…”