“…Inheritance risk and options for family planning (i.e., in vitro fertilization with preimplantation genetic testing, prenatal diagnostic testing, postnatal testing, donor gametes, embryo adoption, and adoption) should be discussed. Once pregnant, hemoglobin level should be monitored closely with transfusion if the mother becomes symptomatic, fetal distress occurs, or hemoglobin is <7 g/dL (70 g/L) [15, 16]. For the fetus at risk for anemia, serial ultrasound should be completed to evaluate middle cerebral artery peak systolic velocity and to assess for other signs of anemia, such as hepatosplenomegaly, cardiovascular compromise, or hydrops fetalis.…”