Recommendations for the management of candidemia in adults in Latin America

Nucci, Márcio; Thompson-Moya, Luis; Guzmán-Blanco, Manuel; In, Tiraboschi; Cortés, Jorge Alberto; Echevarría, Juan; Sifuentes, José; Zurita, Jeannete; Me, Santolaya; T, Alvarado Matute; F, de Queiroz Telles; Colombo, Arnaldo Lopes

doi:10.1016/j.riam.2013.05.007

Cited by 26 publications

(30 citation statements)

References 95 publications

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“…In the current recommendations in unstable patients, an echinocandin is preferred for its lower associated mortality and better safety profile compared to azoles and amphotericin, respectively. 4,26 Our multivariate analysis showed that age and presence of shock at diagnosis of candidemia were significantly associated with mortality. In another series, 27 APACHE II score, steroid use, inadequate dose of fluconazole, and indwelling central venous catheter were independent factors associated with mortality.…”

Section: Discussionmentioning

confidence: 78%

Clinical and epidemiological characteristics and risk factors for mortality in patients with candidemia in hospitals from Bogotá, Colombia

Cortés¹,

Reyes²,

Gómez³

et al. 2014

The Brazilian Journal of Infectious Diseases

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Section: Discussionmentioning

confidence: 78%

Clinical and epidemiological characteristics and risk factors for mortality in patients with candidemia in hospitals from Bogotá, Colombia

Cortés¹,

Reyes²,

Gómez³

et al. 2014

The Brazilian Journal of Infectious Diseases

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“…El uso de equinocandinas se sustenta en estudios prospectivos de asignación aleatoria 51 y meta-análisis 52 . Se debería iniciar el tratamiento con una equinocandina en todos los pacientes y luego, con el paciente estable y la identificación de la especie, des-escalar a fluconazol [53][54][55][56] .…”

Section: Investigación Clínicaunclassified

“…Una de las dudas existentes en el uso de equinocandinas como antifúngicos para el inicio del tratamiento de las candidemias, es la menor sensibilidad de C. parapsilosis frente a ellas 57 . Esto es especialmente importante en nuestra región donde C. parapsilosis es la segunda especie recuperada, aunque la sensibilidad in vitro disminuida no parece tener impacto en la evolución clínica de los pacientes 58 ; este grupo de antifúngicos debe ser considerado de primera línea en el tratamiento 54 .…”

Section: Investigación Clínicaunclassified

Epidemiología, especies, resistencia antifúngica y evolución de las candidemias en un hospital universitario de Buenos Aires, Argentina, durante 16 años

Tiraboschi

Pozzi

Farias

et al. 2017

Rev. chil. infectol.

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“…Most guidelines recommend the use of echinomycin for antifungal infections [18]; however, fluconazole is the most commonly used antifungal drug, and although it has a high mortality rate when used to treat candidemia, it is still widely used in developing countries [19]. In an Indian multicenter study of ICU-acquired candidemia, 64% of the patients were treated with fluconazole [20].…”

Section: Discussionmentioning

confidence: 99%

Analysis of fungal bloodstream infection in intensive care units in the Meizhou region of China: species distribution and resistance and the risk factors for patient mortality

Guangwen

Liao²,

Zhang

et al. 2020

Preprint

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Background : Fungal bloodstream infections (FBI) among intensive care unit (ICU) patients are increasing. Our objective was to characterize the fungal pathogens that cause bloodstream infections and determine the epidemiology and risk factors for patient mortality among ICU patients in Meizhou, China. Methods Eighty-one ICU patients with FBI during their stays were included in the study conducted from January 2008 to December 2017. Blood cultures were performed and the antimicrobial susceptibility profiles of the resulting isolates were determined. Logistic multiple regression and receiver operating characteristics (ROC) curve analysis were used to assess the risk factors for mortality among the cases. Results The prevalence of FBI in ICU patients was 0.38% (81/21,098) with a mortality rate of 35.8% (29/81). Ninety-eight strains of bloodstream-infecting fungi, mainly Candida spp., were identified from these patients. Candida albicans was most common (42.9%). Two strains of C. parapsilosis were no-sensitive to caspofungin, C. glabrata were less than 80% sensitive to azole drugs.. Logistic multiple regression showed that age, serum albumin, Acute Physiology and Chronic Health Evaluation (APACHE) II score, three or more underlying diseases, and length of stay in ICU were independent risk factors for mortality in FBI. ROC curve analysis showed that APACHE II scores > 19 and serum albumin ≤ 25g/L were the best predictors of mortality. Conclusion: Candida spp. predominated with high mortality rates among cases of FBI in ICU. Thus, clinical staff should enhance overall patient monitoring and concurrently monitor fungal susceptibility to reduce mortality rates.

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Recommendations for the management of candidemia in adults in Latin America

Cited by 26 publications

References 95 publications

Clinical and epidemiological characteristics and risk factors for mortality in patients with candidemia in hospitals from Bogotá, Colombia

Clinical and epidemiological characteristics and risk factors for mortality in patients with candidemia in hospitals from Bogotá, Colombia

Epidemiología, especies, resistencia antifúngica y evolución de las candidemias en un hospital universitario de Buenos Aires, Argentina, durante 16 años

Analysis of fungal bloodstream infection in intensive care units in the Meizhou region of China: species distribution and resistance and the risk factors for patient mortality

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