The second year into the COVID-19 pandemic, the year 2021, was a year of hope and perseverance. Facing challenges brought by the ongoing pandemic, the radiology community in Canada and beyond continued to adapt and strive for excellence in patient care, education, and research. These efforts are not only evident in the publishing trends in the CARJ, but also in the interest shown by the radiology community in our publications. The following editorial highlights the 5 most impactful CARJ publications of 2021, as indicated by the number of downloads.