Recommendations for the management of hip and knee osteoarthritis: A systematic review of clinical practice guidelines

Adjunctive electrophysical therapies used in addition to land-based exercise therapy for osteoarthritis of the hip or knee: A systematic review and meta-analysis

“…Non-pharmacological interventions including exercise, education and weight management are recommended core treatments for osteoarthritis (OA) across numerous clinical guidelines [ [1] , [2] , [3] , [4] ]. Other conservative non-pharmacological therapies combined with exercise therapy include electrophysical therapies (EPTs), which deliver thermal, mechanical, light, sound or electrical energy to provide physiological changes and confer therapeutic effects.…”

“…Other conservative non-pharmacological therapies combined with exercise therapy include electrophysical therapies (EPTs), which deliver thermal, mechanical, light, sound or electrical energy to provide physiological changes and confer therapeutic effects. EPTs are largely not recommended in international OA clinical guidelines due to low quality evidence or implausible biological mechanisms [ [1] , [2] , [3] , [4] ], although thermal agents and ultrasound were conditionally recommended in one guideline [ 2 ].…”

Identification of novel potential drugs for the treatment and prevention of osteoarthritis

“…In addition, the extent of chondrocyte apoptosis exhibits a direct correlation with the severity of OA [ 6 ]. While some methods for ameliorating OA symptoms exist, including drug therapy and joint replacement, their effectiveness is constrained, falling short of preventing the onset of OA and impeding its progression [ 7 ]. Moreover, the side effects and limitations of these therapies are difficult to solve [ 8 ].…”

Association of baseline physical activity participation with participant characteristics and outcomes following education and exercise‐therapy in people with knee osteoarthritis: A GLA:D® Australia prospective cohort study

“…Exercise‐therapy and patient education are recommended as first‐line treatments for knee osteoarthritis according to guidelines (Gibbs et al., 2023) to reduce pain and improve knee function (Skou & Roos, 2017). Exercise‐therapy focused on walking or mixed cardiovascular and resistance programs can increase physical activity in the short‐term in people with knee osteoarthritis (Bell et al., 2022).…”