Recommendations for the Prophylactic Management of Skin Reactions Induced by Epidermal Growth Factor Receptor Inhibitors in Patients With Solid Tumors

Abstract

Skin reactions are the most common adverse events attributable to epidermal growth factor receptor (EGFR) inhibitors. This review leads to the recommendation of prophylactic—rather than reactive—management of skin reactions for all patients receiving EGFR inhibitors because appropriate prophylaxis could effectively reduce the severity of skin reactions.

Patient considerations in metastatic colorectal cancer – role of panitumumab

“…Termed the acneiform rash, the EGFR mAb rash differs from acne in that comodones are not often present. Initial symptoms are edema and erythema that progress to papules, nodules, and pustules on the face, neck, chest, back, scalp, and proximal upper extremities, which by the fourth week often crust over 40,41. Pruritus, swelling, and pain are common symptoms that accompany this toxicity.…”

rhEGF Treatment Improves EGFR Inhibitors-Induced Skin Barrier and Immune Defects

“…The most frequently used formulation for EGFRIs-induced skin reactions is the oral or topical application of antibiotics, such as tetracycline family and corticosteroids, alone, or in combination with moisturizers and sunscreen [6][7][8][9][10][11]. Antibiotics, including doxycycline and minocycline, are commonly used to treat acneiform rash, and help reduce its symptoms.…”

Case of cetuximab‐induced disseminated necrotic and maculopapular eruptions: Involvement of an epidermal growth factor receptor inhibitor with epidermal necrosis

“…[1][2][3] However, cetuximab-induced disseminated necrotic eruptions have been extremely limited to date. Here, we present a novel case of cetuximab-induced disseminated necrotic and maculopapular eruptions.…”

“…Epidermal growth factor receptor inhibitors such as cetuximab can develop various cutaneous toxicities. [1][2][3] The most frequent cutaneous toxicity is acneiform eruption and/or papulopustular eruption. Those eruptions are characterized by an intensive infiltration of neutrophils into follicles.…”

“…Case of cetuximab-induced disseminated necrotic and maculopapular eruptions: Involvement of an epidermal growth factor receptor inhibitor with epidermal necrosis Dear Editor, Epidermal growth factor receptor (EGFR) inhibitors such as cetuximab can induce a variety of skin reactions, including as acne-like rash, dry skin, hyperpigmentation and nail disorders. [1][2][3] However, cetuximab-induced disseminated necrotic eruptions have been extremely limited to date. Here, we present a novel case of cetuximab-induced disseminated necrotic and maculopapular eruptions.…”