While growers have reported pressures to minimize wildlife intrusion into produce fields through non-crop vegetation (NCV) removal, NCV provides key ecosystem services. To model food safety and environmental tradeoffs associated with NCV removal, published and publicly available food safety and water quality data from the Northeastern USA were obtained. Because data on NCV removal are not widely available, forest-wetland cover was used as a proxy, consistent with previous studies. Structural equation models (SEMs) were used to quantify the effect of forest-wetland cover on (i) food safety outcomes (e.g., detecting pathogens in soil) and (ii) water quality (e.g., nutrient levels). Based on the SEMs, NCV was not associated with or had a protective effect on food safety outcomes (more NCV was associated with a reduced likelihood of pathogen detection). The probabilities of detecting Listeria spp. in soil (Effect Estimate [EE]=-0.17; P=0.005) and enterohemorrhagic Escherichia coli in stream samples (EE=-0.27; P<0.001) were negatively associated with the amount of NCV surrounding the sampling site. Higher amounts of NCV were also associated with lower nutrient, salinity, and sediment levels and higher dissolved oxygen levels. Total phosphorous levels were negatively associated with the amount of NCV in the upstream watershed (EE=-0.27; P<0.001). Similar negative associations (P<0.05) were observed for other physicochemical parameters, such as nitrate (EE=-0.38). Our findings suggest that NCV should not be considered an inherent produce safety risk or result in farm audit demerits. This study also provides a framework for evaluating environmental trade-offs associated with using specific preharvest food safety strategies.