The development of smoking cessation and relapse-prevention interventions for pregnant and postpartum women is a public health priority. However, researchers have consistently reported substantial difficulty in accruing this population into clinical trials. The problem is particularly acute for relapse-prevention studies, which must recruit women who have already quit smoking because of their pregnancy. Although an important target for tobacco control efforts, these individuals represent an extremely small subgroup of the general population. This paper describes multiple recruitment strategies utilized for a clinical trial of a self-help relapse-prevention program for pregnant women. The effectiveness of the strategies and the direct expense per participant accrued are provided. A proactive recruitment strategy (telephoning women whose phone numbers were purchased from a marketing firm) was ultimately much more successful than a variety of reactive strategies (advertisement, press releases, direct mail, web placement, healthcare provider outreach). There were few differences between proactively and reactively recruited participants on baseline variables; the primary difference was that the former had smoked fewer cigarettes per day and reported lower nicotine dependence prior to quitting. Strengths and limitations of the recruitment strategies are discussed.The risks associated with smoking during pregnancy are well established and highly publicized (Britton, 1998; CDC, 1995; United States Department of Health and Human Services [USDHHS], 1990[USDHHS], , 2001. Consequently, an increasing proportion of women (estimates range from 15% to 60%) spontaneously quit smoking immediately prior to or during their pregnancy (Ershoff et al., 2000;Morasco et al., 2006). However, maintenance of tobacco abstinence among pregnant and postpartum women remains a challenge. Smoking relapse rates among pregnant and postpartum women range from 70-80%, with approximately half of these women resuming smoking within the first twelve weeks postdelivery (Fingerhut et al., 1990;Ockene, 1993;Polanska et al., 2005; USDHHS, 2001). Postpartum smoking exposes the infant to environmental tobacco smoke, which is associated with a range of health problems in children including middle ear infection, asthma, sudden infant death syndrome, behavioral problems, and developmental delays (Charlton, 1994; USDHHS, 2006). Of course, by resuming smoking, the mother also reexposes herself to the myriad health risks associated with tobacco use. Given the high rate of self-quitting among pregnant smokers, as well as the success of interventions designed to motivate pregnant women to quit smoking (Melvin et al., 2000), pregnancy and the early postpartum period appear to offer unique opportunities to provide smoking relapseprevention interventions, although such efforts have met with at best modest success to date (Mullen, 2004).Recruiting participants for clinical trials can be challenging in general (e.g., Harris et al., 2003;Ross et al., 1999), and t...