Reconciling the positive and negative roles of histone H2A.Z in gene transcription

Marques, Maud; Laflamme, Liette; Gervais, Alain; Gaudreau, Luc

doi:10.4161/epi.5.4.11520

Cited by 96 publications

(92 citation statements)

References 76 publications

(103 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, our understanding of the function of H2A.Z in transcription is still quite cloudy. H2A.Z has been proposed to play a role in the recruitment of the coactivators Swi/Snf, Mediator, and SAGA and of the general transcription factor TATA-binding protein (Wan et al 2009;Marques et al 2010). While some studies have suggested roles in activation, most genome-wide studies have shown an inverse correlation between H2A.Z levels and transcriptional levels, which has been interpreted to suggest that H2A.Z helps to poise promoters for activation Zhang et al 2005;Zanton and Pugh 2006).…”

Section: Roles For H2az In Transcriptionmentioning

confidence: 99%

“…Several studies have suggested that H2A.Z controls transcription, DNA repair, genome stability, and the control of antisense transcription (for recent reviews, see Zlatanova and Thakar 2008;Marques et al 2010). H2A.Z is highly conserved among eukaryotes (90% amino acid identity), and it has 60% amino acid identity with H2A.…”

Section: Trans-determinants Of Nucleosome Positioning: General Regulamentioning

confidence: 99%

See 1 more Smart Citation

Chromatin and Transcription in Yeast

2012

View full text Add to dashboard Cite

Understanding the mechanisms by which chromatin structure controls eukaryotic transcription has been an intense area of investigation for the past 25 years. Many of the key discoveries that created the foundation for this field came from studies of Saccharomyces cerevisiae, including the discovery of the role of chromatin in transcriptional silencing, as well as the discovery of chromatin-remodeling factors and histone modification activities. Since that time, studies in yeast have continued to contribute in leading ways. This review article summarizes the large body of yeast studies in this field.

show abstract

Section: Roles For H2az In Transcriptionmentioning

confidence: 99%

Section: Trans-determinants Of Nucleosome Positioning: General Regulamentioning

confidence: 99%

Chromatin and Transcription in Yeast

2012

View full text Add to dashboard Cite

show abstract

“…This may be consistent with the ability of S. cerevisiae SWI/SNF RSC to remodel nucleosomes, thereby creating "inactive" nucleosomal states at the locus. Among the players involved in the control of the nucleosomal state, the H2A.Z variant plays important roles both in activating transcription and antagonizing the spread of heterochromatin into euchromatic regions (Marques et al, 2010). Previously, data obtained from Drosophila and humans showed that H2A.Z levels positively correlate with gene expression (Barski et al, 2007;Mavrich et al, 2008).…”

Section: )mentioning

confidence: 99%

“…Whether BRM acts by modulating H2A.Z incorporation remains to be established, but expression of FLC in the brm mutant does not require the incorporation of H2A.Z, suggesting that this may be the case. H2A.Z is associated with both gene activation and gene repression and is frequently enriched at the 59 and 39 ends of genes (Marques et al, 2010). In the case of FLC, incorporation of H2A.Z at this locus would lead to relative nucleosome instability, thereby facilitating nucleosome displacement by the transcription machinery.…”

Section: Introductionmentioning

confidence: 99%

The BAF60 Subunit of the SWI/SNF Chromatin-Remodeling Complex Directly Controls the Formation of a Gene Loop at FLOWERING LOCUS C in Arabidopsis

et al. 2014

View full text Add to dashboard Cite

SWI/SNF complexes mediate ATP-dependent chromatin remodeling to regulate gene expression. Many components of these complexes are evolutionarily conserved, and several subunits of Arabidopsis thaliana SWI/SNF complexes are involved in the control of flowering, a process that depends on the floral repressor FLOWERING LOCUS C (FLC). BAF60 is a SWI/SNF subunit, and in this work, we show that BAF60, via a direct targeting of the floral repressor FLC, induces a change at the highorder chromatin level and represses the photoperiod flowering pathway in Arabidopsis. BAF60 accumulates in the nucleus and controls the formation of the FLC gene loop by modulation of histone density, composition, and posttranslational modification. Physiological analysis of BAF60 RNA interference mutant lines allowed us to propose that this chromatinremodeling protein creates a repressive chromatin configuration at the FLC locus.

show abstract

“…An important role of H2A.Z in DNA metabolism in general and transcriptional regulation is supported by biochemical and genetic data. [25][26][27] Whether this role is positive or negative depends on the model organism. Specifically, the majority of the recent genome-wide data from yeast support an inverse relationship between H2A.Z and transcriptional activation, in accordance with the detailed analysis of individual promoters.…”

Section: Introductionmentioning

confidence: 99%