2024
DOI: 10.1073/pnas.2406335121
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Reconciling theories of dominance with the relative rates of adaptive substitution on sex chromosomes and autosomes

Yasmine McDonough,
Filip Ruzicka,
Tim Connallon

Abstract: The dominance of beneficial mutations is a key evolutionary parameter affecting the rate and genetic basis of adaptation, yet it is notoriously difficult to estimate. A leading method to infer it is to compare the relative rates of adaptive substitution for X-linked and autosomal genes, which—according to a classic model by Charlesworth et al. (1987)—is a simple function of the dominance of new beneficial mutations. Recent evidence that rates of adaptive substitution are faster for X-linked genes implies, acco… Show more

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