2014
DOI: 10.1007/s12291-014-0451-3
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Reconnoitring the Status of Prostate Specific Antigen and its Role in Women

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Cited by 9 publications
(6 citation statements)
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“…However, other studies have not been able to demonstrate prognostic value, despite promising results when PSA is measured in tissue samples from the tumor ( 187 , 188 ). In general, using circulating PSA as a biomarker for breast cancer among women remains a challenge, as PSA levels are very low compared to men, and often undetectable ( 106 ). Although more sensitive assays are being developed ( 104 ), further research with large cohorts of patients is required before this marker is used routinely in breast cancer management.…”
Section: Measurements In Bloodmentioning
confidence: 99%
“…However, other studies have not been able to demonstrate prognostic value, despite promising results when PSA is measured in tissue samples from the tumor ( 187 , 188 ). In general, using circulating PSA as a biomarker for breast cancer among women remains a challenge, as PSA levels are very low compared to men, and often undetectable ( 106 ). Although more sensitive assays are being developed ( 104 ), further research with large cohorts of patients is required before this marker is used routinely in breast cancer management.…”
Section: Measurements In Bloodmentioning
confidence: 99%
“…The prostate‐specific antigen (PSA) was believed to be produced exclusively by prostatic epithelial cells, and it was considered the biochemical marker of prostatic cancer (Carlsson & Vickers, 2020 ). However, circumstantial evidence confirmed that, in both women and men, other tissues and organs express PSA (Dash, 2015 ; Eklund et al., 2017 ; Musrap & Diamandis, 2016 ; Pérez‐Ibave et al., 2018 ). Now, it is widely accepted that PSA is not prostate‐specific (Mashkoor et al., 2013 ); hence, its screening utility has been questioned (Filella, 2020 ; Gandaglia et al., 2019 ).…”
Section: Introductionmentioning
confidence: 97%
“…However, circumstantial evidence confirmed that, in both women and men, other tissues and organs express PSA (Dash, 2015;Eklund et al, 2017;Musrap & Diamandis, 2016;Pérez-Ibave et al, 2018). Now, it is widely accepted that PSA is not prostate-specific (Mashkoor et al, 2013); hence, its screening utility has been questioned (Filella, 2020;Gandaglia et al, 2019).…”
Section: Introductionmentioning
confidence: 99%
“…The central zone is resistant to both inflammation and carcinoma (3) . Stem cells reside in the basal epithelial cell compartment and are the foundation for all other types of cells in the epithelium and neuroendocrine cells, where testosterone is converted to more potent 5-alpha dihydrotestosterone (DHT) via 5α -reductase (4,5) . Approximately 70-90 percent of total PSA is present as a complexed form in serum Free PSA (fPSA) associated with various different endogenous protease inhibitors that prevent damage to PSA protease function.…”
Section: Introductionmentioning
confidence: 99%