Reconsideration of the clinical and histopathological significance of angiogenesis in prostate cancer: Usefulness and limitations of microvessel density measurement

Miyata, Yasuyoshi; Sakai, Hideki

doi:10.1111/iju.12840

Cited by 45 publications

(48 citation statements)

References 66 publications

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“…Various antibodies were found to be associated with prognostic factors in some of the studies while some of the studies support the opposing opinions. Miyata et al explained the reason for this discrepancy with different methodology of measuring MVD in cancers (10). In order to determine the MVD in our study, the hot spot method of Weidner et al, has been used (5).…”

Section: Discussionmentioning

confidence: 99%

Relation between clinical, histopathological properties and microvessel density assessed by CD105 and CD31 in prostate carcinoma

Akincioglu¹,

Seçinti²,

Kandemir³

et al. 2016

Acta Oncol Tur.

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ÖZETGiriş ve Amaç: Bu çalışmayı, prostat kanserinde, tümör dokusunda ve tümör çevresinde CD105 ve CD31 ile araştırılan mikrovasküler yoğunluğun (MVY) histopatolojik ve klinik bulgularla ilişkisini araştırmak amacıyla planladık. Yöntem ve Gereçler: Çalışmamızda, Patoloji Bölümünde incelenmiş 100 radikal prostatektomi materyali klinik ve histopatolojik bulguları açısından retrospektif olarak değerlendirildi. Her bir materyaldeki tümör dokusuna ve tümör çevresine CD105 ve CD31 immünohistokimyasal belirteçleri uygulandı. Tümoral ve peritümöral CD105 ve CD31 ile MVY ekspresyonu, klinik ve histopatolojik bulgularla karşılaştırıldı. Bulgular: Tümör dokusunda CD105 ve CD31 ile MVY, tümör çevresindekinden anlamlı olarak fazla bulundu (p<0.001). Tümör çevresindeki CD105 ile boyanan damar sayısı, tümör çevresindeki CD31 ile boyanan damar sayısından anlamlı derecede düşük bulundu (p<0.001). Tümör dokusundaki CD105 MVY ile preoperatif serum total PSA düzeyi, tümör hacmi, perinöral invazyon, lenf düğümü metastazı ve lokal invazyon arasında anlamlı ilişki bulundu (sırasıyla r=0,338 ve p<0,001, p= 0,003, p= 0,009, p= 0,044). Tümör dokusundaki CD31 MVY ekspresyonu ile patolojik evre, cerrahi sınırda tümör bulunması ve veziküloseminalis invazyonu arasında anlamlı ilişki bulundu (sırasıyla r=0,228 ve p= 0,022, p=0,034).Tümör çevresindeki CD105 ve CD31 MVY ekspresyonu ile klinik ve histopatolojik bulgular arasında anlamlı ilişki görülmedi (p > 0,05). Tartışma ve Sonuç: Tümör dokusundaki CD105 ve CD31 MVY'nun, prognostik açıdan önemli klinik bulgularla ilişkili olması, tümör pogresyonunda anjiogenezin önemini vurgulamaktadır. Bu bulgu anti-anjiojenik ajanları içeren yeni tedavi modalitelerinin gelişmesini sağlayacaktır. Anahtar Kelimeler: Prostat kanseri, CD31 Antijeni, CD105 Antijeni, Mikrovasküler yoğunluk ABSTRACT Introduction: We designed this study in order to investigate the relation between histopathological and clinical properties in prostatic carcinoma patients and microvessel density (MVD) of tumoral and peritumoral tissue, assessed by CD105 and CD31 expression. Methods: A total of 100 radical prostatectomy samples, have been evaluated retrospectively with clinical and histopathological findings. Immunohistochemical markers of CD105 and CD31 were applied to the tumoral tissue and surroundings of tumor. Relation between tumoral and peritumoral CD105, CD31 and clinical or histopathological findings was evaluated. Results: CD105 and CD31 together with MVD have been found more significant in the tumoral tissue than the periphery (p<0,001). CD105 expression in the peritumoral tissue was significantly lower than the CD31 expression. A significant correlation has been found between CD105 MVD in the tumoral tissue and the preoperative serum total PSA levels and tumor volume (r=0.259, p=0.009, r=0.198, p=0.049, respectively). Tumoral CD105 expression was significantly higher in cases with perineural invasion, lymph node metastasis and local invasion (p=0.003, p=0.009, p=0.044). CD31 expression was significantly correlated with path...

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Section: Discussionmentioning

confidence: 99%

Relation between clinical, histopathological properties and microvessel density assessed by CD105 and CD31 in prostate carcinoma

Akincioglu¹,

Seçinti²,

Kandemir³

et al. 2016

Acta Oncol Tur.

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“…Coexistence of a myelolipomatous lesion and a hemangioma is uncommon, with only one reported case. 2 We present a case of a cavernous hemangioma associated with a myelolipomatous metaplasia in the adrenal gland. A 77-year-old man was referred to the Department of Urology at Shinonoi General Hospital, Nagano, Japan, for treatment of a left adrenal tumor.…”

Section: Conflict Of Interestmentioning

confidence: 98%

“…2 They paid attention to the reasons for the conflicting MVD results, such as differences in population size, the pathological background, the antibody used for detection endothelial cells, the counting method, personal experience and selection of the tumor area. 2 However, MVD is substantially limited by the highly irregular geometry that the microvascular system assumes in "real space." Angiogenesis is a dynamic process that is discontinuous in "space" and "time."…”

mentioning

confidence: 99%

“…2 Conversely, Taverna et al showed the influence of the structural diversity of the cancer-related vasculature on the evaluation of the significance and role of angiogenesis in cancer tissues. 1 Briefly, neovasculatures in cancer tissues show diversity in vessel sizes, shapes and connecting patterns, because they have complex forms of branched anatomical structure.…”

mentioning

confidence: 99%

“…As we pointed out in the previous review, it is difficult to decide on a single antibody for detection of "cancer-specific" endothelial cells, because they have marked diversity depending on the malignant potential of cancer cells, stage and surrounding conditions. 2 Furthermore, newer molecules and factors are being developed even now. We believe that constant investigations and more detailed analyses by using new technology are essential to obtain unbiased and versatile results on the pathological significance and prognostic role of angiogenic status in cancer patients.…”

mentioning

confidence: 99%

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Response to Re: Reconsideration of the clinical and histopathological significance of angiogenesis in prostate cancer: Usefulness and limitations of microvessel density measurement

Miyata

Sakai

2015

Int J of Urology

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Re: Reconsideration of the clinical and histopathological significance of angiogenesis in prostate cancer: Usefulness and limitations of microvessel density measurement Although there are currently no biomarkers of net angiogenic activity in prostate cancer (PCa), microvessel density (MVD) represents the surrogate biomarker of angiogenesis, and has been shown to correlate with progression, and other upstream and downstream regulators of angiogenesis.1 Miyata and Sakai reviewed the relationships between MVD and clinicopathological features, progression and survival in patients with PCa.2 They paid attention to the reasons for the conflicting MVD results, such as differences in population size, the pathological background, the antibody used for detection endothelial cells, the counting method, personal experience and selection of the tumor area.2 However, MVD is substantially limited by the highly irregular geometry that the microvascular system assumes in "real space." Angiogenesis is a dynamic process that is discontinuous in "space" and "time." The main feature of the newly generated vasculature is the structural diversity of the vessel sizes, shapes and connecting patterns. At a basic level, the practice of histology involves looking at an image (visual perception) and interpreting what is seen (cognition), and experience gives a histologist the perceptual and cognitive skills to know what information to look for, and how to interpret that information on the basis of the accumulated information processed from previous encounters with similar images. What makes the task extremely difficult is the high degree of "geometrical variability," and histologists can never see all the possible variations no matter how long they practice or how many images they see. However, objective computer-aided descriptors of the vascular complexity can be abstracted from the fractal geometry. The vascular system can be geometrically depicted as a fractal network of vessels that irregularly branch with a systematic reduction in their length and diameter. Fractal objects are mainly characterized by four properties: (i) the irregularity of their shape; (ii) the "self-similarity" of their structure; (iii) their fractal dimension; and (iv) scaling, which means that the measured properties depends on the scale at which they are measured.3 In 2005, we introduced the surface fractal dimension, D s , as an index of twodimensional geometrical complexity of vascular network, and evaluated its behavior during computer-simulated changes in vessel density and distribution. 3 We showed that D s depends on: (i) the number of vessels; (ii) the spatial relationships between the vessels; and (iii) the interactions between the vessels and the surrounding environment.3 Recently, we investigated 280 prostate biopsy sections from a series of 70 patients with low-risk PCa (Gleason score 3 + 3, prostatespecific antigen <10 ng/mL) and clinical stage T1c using an image analysis system that automatically estimates the D s. 4Our results showed that biopsy sect...

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VERDICT‐AMICO: Ultrafast fitting algorithm for non‐invasive prostate microstructure characterization

Bonet‐Carne¹,

Johnston²,

Daducci

et al. 2018

NMR in Biomedicine

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VERDICT (vascular, extracellular and restricted diffusion for cytometry in tumours) estimates and maps microstructural features of cancerous tissue non‐invasively using diffusion MRI. The main purpose of this study is to address the high computational time of microstructural model fitting for prostate diagnosis, while retaining utility in terms of tumour conspicuity and repeatability. In this work, we adapt the accelerated microstructure imaging via convex optimization (AMICO) framework to linearize the estimation of VERDICT parameters for the prostate gland. We compare the original non‐linear fitting of VERDICT with the linear fitting, quantifying accuracy with synthetic data, and computational time and reliability (performance and precision) in eight patients. We also assess the repeatability (scan‐rescan) of the parameters. Comparison of the original VERDICT fitting versus VERDICT‐AMICO showed that the linearized fitting (1) is more accurate in simulation for a signal‐to‐noise ratio of 20 dB; (2) reduces the processing time by three orders of magnitude, from 6.55 seconds/voxel to 1.78 milliseconds/voxel; (3) estimates parameters more precisely; (4) produces similar parametric maps and (5) produces similar estimated parameters with a high Pearson correlation between implementations, r 2 > 0.7. The VERDICT‐AMICO estimates also show high levels of repeatability. Finally, we demonstrate that VERDICT‐AMICO can estimate an extra diffusivity parameter without losing tumour conspicuity and retains the fitting advantages. VERDICT‐AMICO provides microstructural maps for prostate cancer characterization in seconds.

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Reconsideration of the clinical and histopathological significance of angiogenesis in prostate cancer: Usefulness and limitations of microvessel density measurement

Cited by 45 publications

References 66 publications

Relation between clinical, histopathological properties and microvessel density assessed by CD105 and CD31 in prostate carcinoma

Relation between clinical, histopathological properties and microvessel density assessed by CD105 and CD31 in prostate carcinoma

Response to Re: Reconsideration of the clinical and histopathological significance of angiogenesis in prostate cancer: Usefulness and limitations of microvessel density measurement

VERDICT‐AMICO: Ultrafast fitting algorithm for non‐invasive prostate microstructure characterization

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