Reconstituting the epidemic history of mono lineage of HIV-1 CRF01_AE in Guizhou province, Southern China

Zeng, Haiyan; Sun, Binlian; Li, Lingnuo; Li, Yanpeng; Liu, Yong; Xiao, Yumei; Jiang, Yan; Yang, Rongge

doi:10.1016/j.meegid.2014.05.006

Cited by 9 publications

(7 citation statements)

References 29 publications

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“…The possible recombinations of inter-genotypes occurring among the consensus sequence were subtypes C, 07_BC, and 01_AE (query B), subtypes B, C, 07_BC, and 01_AE (queries C and F), subtypes A1 and A2 (query D), and subtypes C and 07_BC (query E). Wang et al, 2008;Li et al, 2011;Wu et al, 2013;Zeng et al, 2014]. Consistent with the results reported in many areas of China, two independent CRF01_AE lineages were demonstrated in Harbin city.…”

Section: Discussionsupporting

confidence: 88%

“…CRF01_AE had the fastest growth rate among all circulating HIV‐1 subtypes and is currently the dominant strain. The CRF01_AE strain quickly emerged as the most widespread in recent years, and became the principal strain in persons who were infected with HIV through a sexual route (homosexual and heterosexual) [Zhang et al, ; Wang et al, ; Li et al, ; Wu et al, ; Zeng et al, ]. Consistent with the results reported in many areas of China, two independent CRF01_AE lineages were demonstrated in Harbin city.…”

Section: Discussionmentioning

confidence: 59%

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Molecular epidemiology is becoming complex under the dynamic HIV prevalence: The perspective from Harbin, China

Lei

Song

Cao

et al. 2015

Journal of Medical Virology

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Unlike most areas of China, HIV transmission via men who have sex with men (MSM) is increasing rapidly, and has become the main route of HIV transmission in Harbin city. The purpose of the current study was to elaborate the molecular epidemiologic characteristics of the new HIV epidemic. Eighty-one HIV-1 gag gene sequences (HXB2:806-1861) from local HIV infections were isolated; CRF01_AE predominated among HIV infections (71.6%), followed by subtype B (16.5%), CRF07_BC (6.2%), and unique recombinant strains (URFs; 6.2%). URFs were most often identified in the MSM population, which consisted of a recombination of CRF01_AE with subtype B or CRF07_BC. Six clusters were formed in this analysis; clusters I and II mainly circulated in southwest China. Clusters III and IV mainly circulated in southwest, southeast, and central China. Clusters V and VI mainly circulated in north and northeast China. Clusters III and IV may facilitate the transmission of the CRF01_AE strain from the southwest to the north and northeast regions of China. HIV subtypes are becoming diverse with the persistent epidemic in this geographic region. In brief, our results indicate that the molecular epidemiology of HIV is trending to be more complex. Thus, timely molecular epidemiologic supervision of HIV is necessary, especially for the MSM population.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 59%

Molecular epidemiology is becoming complex under the dynamic HIV prevalence: The perspective from Harbin, China

Lei

Song

Cao

et al. 2015

Journal of Medical Virology

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“…Similarly, the overall low prevalence of the CRFs_cpx lineages carrying fragments of those ancient may reflect a later emergence of these variants when compared to more prevalent HIV-1 subtypes and CRFs. The evolutionary analyses performed here, however, support that complex CRFs probably started to circulate in Central Africa between the late 1950s and the late 1960s, which coincides with the estimated onset date of several prevalent HIV-1 group M clades including: subtype A1 (T MRCA ~ 1955) [41], subtype C (T MRCA ~ 1955–1965) [41, 50, 51], subtype F1 (T MRCA ~ 1960–1970) [52, 53], subtype G (T MRCA ~ 1965–1970) [41, 54], the CRF01_AE (T MRCA ~ 1970–1975) [41, 55, 56], and the CRF02_AG (T MRCA ~ 1965–1975) [41, 57, 58]. The estimated T MRCA also overlaps with a period of demographic transition of the HIV-1 group M in the DRC around 1960 (95% HPD: 1952–1968), from an early phase of relatively slow exponential growth to a second phase of faster exponential growth [2].…”

Section: Discussionsupporting

confidence: 53%

Time-scale of minor HIV-1 complex circulating recombinant forms from Central and West Africa

Delatorre

Bello

2016

BMC Evol Biol

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BackgroundSeveral HIV-1 circulating recombinant forms with a complex mosaic structure (CRFs_cpx) circulate in central and western African regions. Here we reconstruct the evolutionary history of some of these complex CRFs (09_cpx, 11_cpx, 13_cpx and 45_cpx) and further investigate the dissemination dynamic of the CRF11_cpx clade by using a Bayesian coalescent-based method.ResultsThe analysis of two HIV-1 datasets comprising 181 pol (36 CRF09_cpx, 116 CRF11_cpx, 20 CRF13_cpx and 9 CRF45_cpx) and 125 env (12 CRF09_cpx, 67 CRF11_cpx, 17 CRF13_cpx and 29 CRF45_cpx) sequences pointed to quite consistent onset dates for CRF09_cpx (~1966: 1958–1979), CRF11_cpx (~1957: 1950–1966) and CRF13_cpx (~1965: 1958–1973) clades; while some divergence was found for the estimated date of origin of CRF45_cpx clade [pol = 1970 (1964–1976); env = 1960 (1952–1969)]. Phylogeographic reconstructions indicate that the HIV-1 CRF11_cpx clade most probably emerged in Cameroon and from there it was first disseminated to the Central Africa Republic and Chad in the early 1970s and to other central and western African countries from the early 1980s onwards. Demographic reconstructions suggest that the CRF11_cpx epidemic grew between 1960 and 1990 with a median exponential growth rate of 0.27 year−1, and stabilized after.ConclusionsThese results reveal that HIV-1 CRFs_cpx clades have been circulating in Central Africa for a period comparable to other much more prevalent HIV-1 group M lineages. Cameroon was probably the epicenter of dissemination of the CRF11_cpx clade that seems to have experienced a long epidemic growth phase before stabilization. The epidemic growth of the CRF11_cpx clade was roughly comparable to other HIV-1 group M lineages circulating in Central Africa.Electronic supplementary materialThe online version of this article (doi:10.1186/s12862-016-0824-8) contains supplementary material, which is available to authorized users.

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“…HIV-1 CRF01_AE, which predominates in sexual risk populations, is the prevalent CRF in the world, especially in Asia. 1 , 20 Multiple lineages of CRF01_AE strains were introduced into China during early-middle 1990s. 21 Recent studies have reported that CRF01_AE became the dominant subtype in Guangxi Province, 15 , 16 , 18 which is consistent with the findings of our study.…”

Section: Discussionmentioning

confidence: 99%

“… 19 However, CRF01_AE strains in Guizhou were distributed in 4 major clusters. 20 Recent studies also found that CRF01_AE in Hong Kong likely originated from 3 separate clusters. 6 Later, there were estimated to be at least 4 clusters in China, 12 whereas the analyses of near-full-length genome (NFLG) sequences revealed 7 different CRF01_AE clusters in China.…”

Section: Introductionmentioning

confidence: 97%

Genetic Characteristics of CRF01_AE Among Newly Diagnosed HIV-1-Infected 16- to 25-Year Olds in 3 Geographic Regions of Guangxi, China

et al. 2015

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Reconstituting the epidemic history of mono lineage of HIV-1 CRF01_AE in Guizhou province, Southern China

Cited by 9 publications

References 29 publications

Molecular epidemiology is becoming complex under the dynamic HIV prevalence: The perspective from Harbin, China

Molecular epidemiology is becoming complex under the dynamic HIV prevalence: The perspective from Harbin, China

Time-scale of minor HIV-1 complex circulating recombinant forms from Central and West Africa

Genetic Characteristics of CRF01_AE Among Newly Diagnosed HIV-1-Infected 16- to 25-Year Olds in 3 Geographic Regions of Guangxi, China

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