2023
DOI: 10.1101/2023.11.02.565200
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Reconstructing prevalence dynamics of wildlife pathogens from pooled and individual samples

Benny Borremans,
Caylee A Falvo,
Daniel E Crowley
et al.

Abstract: Pathogen transmission studies require sample collection over extended periods, which can be challenging and costly, especially in the case of wildlife. A useful strategy can be to collect pooled samples, but this presents challenges when the goal is to estimate infection prevalence dynamics. In particular, pooling typically results in a dilution effect where mixing positive and negative or lower-concentration samples lowers the overall concentration. Simultaneously, a pooled sample is more likely to test posit… Show more

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