From April to July 2021, West Crater at Iwo-Yama, Kirishima Volcanic Complex, Japan, was repeatedly filled with hydrothermal water and subsequently evacuated. The overall cycle lasted 14–70 h, and the course of a single cycle followed this sequence of phases: (i) steam effusion disappeared 20–40 min before hydrothermal discharge; (ii) hydrothermal discharge occurred, generating a hydrothermal water pool; (iii) steam effusion resumed and gradually increased; and (iv) drain-back (evacuation) of the hydrothermal water occurred 1–1.5 h before the onset of the next hydrothermal discharge. We used multi-parametric observations (optical camera, thermometer, electric self-potential (SP), seismometer, acoustic sensor, and tiltmeter) to investigate the cause of the cyclic hydrothermal discharge. A change in SP data occurred approximately 2 h before the onset of hydrothermal discharge. However, the change in SP was small when hydrothermal discharge did not occur. The temporal change in SP is inferred to have been caused by groundwater flow through the region below West Crater, implying that groundwater flow was occurring 2 h before hydrothermal discharge. The polarity of SP change suggests that groundwater flowed toward the region underlying the vents. Seismic signals in the frequency range of < 20 Hz decreased 15–45 min after the onset of change in SP. This seismic signal pattern is inferred to have been caused by bubble activity in boiling fluid. We interpret that the inflow of cold groundwater inhibited boiling activity in the conduit, which in turn caused the cessation of both steam effusion and seismic activity. SP data suggest that the inflow of cold groundwater gradually decreased before hydrothermal discharge. Pressurization sufficient to force the water in the upper part of the conduit to ascend could have built up in the lower part of the conduit owing to a decrease in the input of groundwater into the upper part of the conduit and the continuing supply of steam bubbles and hot water. This increase in pressure finally led to hydrothermal discharge at the surface. We suggest that the inflow of cold groundwater into the geyser conduit was the key control on the occurrence and cyclicity of hydrothermal discharge in West Crater at Iwo-Yama.