Reconstruction-free positron emission imaging: Fact or fiction?

Schramm, Georg

doi:10.3389/fnume.2022.936091

Front. Nucl. Med.

2022

DOI: 10.3389/fnume.2022.936091

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Reconstruction-free positron emission imaging: Fact or fiction?

Georg Schramm

Abstract: In PET, we use the general term "projection" for (weighted) line or volume integrals along a line (LOR) or tube of response (TOR) connecting two photon detectors.Moreover, inversion methods to invert the more general three-dimensional X-ray transform were developed ( ).

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Cited by 3 publications

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Positron emission tomography: its 65 years and beyond

Belcari,

Bisogni,

Del Guerra

2024

Riv. Nuovo Cim.

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Positron emission tomography (PET) is a well-established imaging technique for “in-vivo” molecular imaging. In this review, after a brief history of PET, its physical principles and the technology developed for bringing PET from a bench experiment to a clinically indispensable instrument are presented. The limitations and performance of the PET tomographs are discussed, both for the hardware and software aspects. The status of the art of clinical, pre-clinical and hybrid scanners (i.e., PET/CT and PET/MR) is reported. Finally, the actual trend and the recent and future technological developments are illustrated. The current version of this paper is the second edition of the original version published in 2016 (Rivista del Nuovo Cimento, Vol 39(4) 2016, pp. 156–213). The authors decided to keep the same structure of the paper, operating corrections of some typos, and adjustments. However, we added a description of the most recent PET developments that took place in the last 10 years completed with the addition of the most relevant references. These topics are now described in detail and cover the last two chapters of the paper.

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Positron emission tomography: its 65 years and beyond

Belcari,

Bisogni,

Del Guerra

2024

Riv. Nuovo Cim.

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Total Body PET/CT: Future Aspects

Godinez,

Mingels,

Bayerlein

et al. 2025

Seminars in Nuclear Medicine

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Long-axial field-of-view PET/CT: perspectives and review of a revolutionary development in nuclear medicine based on clinical experience in over 7000 patients

et al. 2023

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Recently introduced long-axial field-of-view (LAFOV) PET/CT systems represent one of the most significant advancements in nuclear medicine since the advent of multi-modality PET/CT imaging. The higher sensitivity exhibited by such systems allow for reductions in applied activity and short duration scans. However, we consider this to be just one small part of the story: Instead, the ability to image the body in its entirety in a single FOV affords insights which standard FOV systems cannot provide. For example, we now have the ability to capture a wider dynamic range of a tracer by imaging it over multiple half-lives without detrimental image noise, to leverage lower radiopharmaceutical doses by using dual-tracer techniques and with improved quantification. The potential for quantitative dynamic whole-body imaging using abbreviated protocols potentially makes these techniques viable for routine clinical use, transforming PET-reporting from a subjective analysis of semi-quantitative maps of radiopharmaceutical uptake at a single time-point to an accurate and quantitative, non-invasive tool to determine human function and physiology and to explore organ interactions and to perform whole-body systems analysis. This article will share the insights obtained from 2 years’ of clinical operation of the first Biograph Vision Quadra (Siemens Healthineers) LAFOV system. It will also survey the current state-of-the-art in PET technology. Several technologies are poised to furnish systems with even greater sensitivity and resolution than current systems, potentially with orders of magnitude higher sensitivity. Current barriers which remain to be surmounted, such as data pipelines, patient throughput and the hindrances to implementing kinetic analysis for routine patient care will also be discussed.

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Reconstruction-free positron emission imaging: Fact or fiction?

Abstract: In PET, we use the general term "projection" for (weighted) line or volume integrals along a line (LOR) or tube of response (TOR) connecting two photon detectors.Moreover, inversion methods to invert the more general three-dimensional X-ray transform were developed ( ).

Cited by 3 publications

References 30 publications

Positron emission tomography: its 65 years and beyond

Positron emission tomography: its 65 years and beyond

Total Body PET/CT: Future Aspects

Long-axial field-of-view PET/CT: perspectives and review of a revolutionary development in nuclear medicine based on clinical experience in over 7000 patients

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