High-intensity focused ultrasound (HIFU) ablation is a safe and effective minimally invasive option for treating uterine fibromas, but it can cause complications such as abdominal wall defects. Reconstruction of such defects can be challenging, but a latissimus dorsi musculocutaneous free flap can be used to restore the integrity of the myofascial layer and provide external cutaneous coverage. Herein, we present a case report of a 37-year-old woman who underwent HIFU for an 8-cm uterine fibroma and subsequently developed a large abdominal wall defect with necrosis of the rectus muscle. The latissimus dorsi musculocutaneous free flap was used to reconstruct the rectus muscle and cover the abdominal soft tissue, resulting in successful engraftment without complications. We present our experience using a latissimus dorsi musculocutaneous free flap to reconstruct a large HIFU-induced composite defect in the abdominal wall.