“…6,7 Local recurrence rate, high Campanacci stage, and surgical method, such as curettage, are significant risk factors for lung metastasis. 6 Treatment options include curettage 8 alone or in combination with local adjuvants, such as polymethylmethacrylate cement, alcohol, phenol, hydrogen peroxide, zinc chloride, 9 cryoablation with liquid nitrogen, 10 radiation, 11 supportive neoadjuvant systemic therapy with denosumab as an RANKL inhibitor, 5 resection, 12 or amputation, 2,13 whereby wide tumor resection has lower recurrence rates compared with simple curettage. However, wide tumor resection leading to large osseous defects especially with articular involvement significantly impairs hand function.…”