Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics

Xu, Songfeng; Lin, Kaili; Wang, Zhen; Chang, Jiang; Wang, Lin; Lu, Jianxi; Ning, Congqin

doi:10.1016/j.biomaterials.2008.03.013

Cited by 404 publications

(305 citation statements)

References 36 publications

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“…Apatite mineralization of silicate materials, such as CaSiO 3 ceramics, 45S5 bioglass, etc. is thought to be an important phenomenon in the chemical interactions between the implant materials and the bone tissue, which ultimately affects the in vivo osteogenesis of the bone grafting materials [34][35][36]. In this study, MBG/silk scaffolds had an obvious apatite mineralization in SBF, whereas neither BG/silk nor pure silk scaffolds induced apatite mineralization.…”

Section: Mbg Powders-incorporated Silk Scaffolds 221 Preparation Cmentioning

confidence: 58%

“…In the present study, we show that MBG/silk has a better apatite-mineralization ability than does BG/silk, leading us to draw the tentative conclusion that this may be one of the most important factors to improve new-bone formation. (2) The faster rate of dissolution and Si ion release of the MBG/silk scaffolds compared to BG/silk scaffolds may enhance newbone formation; this is supported by a study that showed that CaSiO 3 ceramics has significantly faster rate of degradation than does β-tricalcium phosphate ceramics and leads to an improved in vivo osseointegration [34]. It has been reported that Si ions may be associated with the initiation of pre-osseous tissue mineralization, both in periosteal or in endochondral ossification, in the early stages of calcification [41,42].…”

Section: The In Vivo Osteogenesis Of Mbg-incorporated Silk Scaffoldsmentioning

confidence: 97%

“…14c and d) [33]. There are three reasons that best explains why MBG/silk scaffolds have improved newbone formation, compared to BG/silk scaffolds [33]: (1) apatite mineralization plays an important role in bone repair and studies suggest that apatite mineralization of 45S5 bioglass [36], A-W bioactive glass ceramics [39] and CaSiO 3 ceramics [34,40], is the direct factor influencing the in vivo osteogenesis potential of these materials. In the present study, we show that MBG/silk has a better apatite-mineralization ability than does BG/silk, leading us to draw the tentative conclusion that this may be one of the most important factors to improve new-bone formation.…”

Section: The In Vivo Osteogenesis Of Mbg-incorporated Silk Scaffoldsmentioning

confidence: 99%

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Mesopore Bioglass/Silk Composite Scaffolds for Bone Tissue Engineering

Wu¹,

Xiao²

2011

Biomaterials Science and Engineering

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Section: Mbg Powders-incorporated Silk Scaffolds 221 Preparation Cmentioning

confidence: 58%

Section: The In Vivo Osteogenesis Of Mbg-incorporated Silk Scaffoldsmentioning

confidence: 97%

Section: The In Vivo Osteogenesis Of Mbg-incorporated Silk Scaffoldsmentioning

confidence: 99%

See 1 more Smart Citation

Mesopore Bioglass/Silk Composite Scaffolds for Bone Tissue Engineering

Wu¹,

Xiao²

2011

Biomaterials Science and Engineering

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“…The in vivo boneregenerative capacity of calcium silicate was investigated in rabbits and results were compared with TCP. Micro-CT and histomorphometric analysis showed resorption and newly formed bone with both materials, but resorption as well as bone formation of calcium silicate was higher than that of TCP (Xu et al 2008). Wistar rats were used to histologically evaluate the healing of surgically created defects on the tibia after implantation of bioactive glass.…”

Section: Homogenous Chemical Compositionmentioning

confidence: 99%

Biomaterials Applicable for Alveolar Sockets Preservation: In Vivo and In Vitro Studies

Kunert‐Keil¹,

Gredes²,

Gedrange³

2011

Implant Dentistry - The Most Promising Discipline of Dentistry

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“…6,7 Several studies were able to demonstrate the benefit of early bone ingrowth and repair through the incorporation of silicon into porous HA or calcium silicate ceramics. 8,9,13,31 Others investigated the influence of silicon on cell proliferation and osteogenic signaling in human mesenchymal stem cells (MSC) and could show transient osteogenic signals in MSC. 10,11 A silica gel-embedded, non-sintered nanocrystalline HA bone substitute (NanoBone ® ; Artoss GmbH, Rostock, Germany) with interconnecting pores from nanometer to millimeter range was recently developed and approved.…”

Section: Introductionmentioning

confidence: 99%

Autologous serum improves bone formation in a primary stable silica-embedded nanohydroxyapatite bone substitute in combination with mesenchymal stem cells and rhBMP-2 in the sheep model

Boos

Weigand

Deschler

et al. 2014

IJN

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New therapeutic strategies are required for critical size bone defects, because the gold standard of transplanting autologous bone from an unharmed area of the body often leads to several severe side effects and disadvantages for the patient. For years, tissue engineering approaches have been seeking a stable, axially vascularized transplantable bone replacement suitable for transplantation into the recipient bed with pre-existing insufficient conditions. For this reason, the arteriovenous loop model was developed and various bone substitutes have been vascularized. However, it has not been possible thus far to engineer a primary stable and axially vascularized transplantable bone substitute. For that purpose, a primary stable silica-embedded nanohydroxyapatite (HA) bone substitute in combination with blood, bone marrow, expanded, or directly retransplanted mesenchymal stem cells, recombinant human bone morphogenetic protein 2 (rhBMP-2), and different carrier materials (fibrin, cell culture medium, autologous serum) was tested subcutaneously for 4 or 12 weeks in the sheep model. Autologous serum lead to an early matrix change during degradation of the bone substitute and formation of new bone tissue. The best results were achieved in the group combining mesenchymal stem cells expanded with 60 μg/mL rhBMP-2 in autologous serum. Better ingrowth of fibrovascular tissue could be detected in the autologous serum group compared with the control (fibrin). Osteoclastic activity indicating an active bone remodeling process was observed after 4 weeks, particularly in the group with autologous serum and after 12 weeks in every experimental group. This study clearly demonstrates the positive effects of autologous serum in combination with mesenchymal stem cells and rhBMP-2 on bone formation in a primary stable silica-embedded nano-HA bone grafting material in the sheep model. In further experiments, the results will be transferred to the sheep arteriovenous loop model in order to engineer an axially vascularized primary stable bone replacement in clinically relevant size for free transplantation.

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Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics

Cited by 404 publications

References 36 publications

Mesopore Bioglass/Silk Composite Scaffolds for Bone Tissue Engineering

Mesopore Bioglass/Silk Composite Scaffolds for Bone Tissue Engineering

Biomaterials Applicable for Alveolar Sockets Preservation: In Vivo and In Vitro Studies

Autologous serum improves bone formation in a primary stable silica-embedded nanohydroxyapatite bone substitute in combination with mesenchymal stem cells and rhBMP-2 in the sheep model

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