Reconstruction of Congenital Cranial Defect Using Autologous Bone Graft in Aplasia Cutis Congenita

Abstract

Many methods have been devised to repair cranial defects. Here, we report the use of a simple technique for the repair of a congenital cranial defect associated with aplasia cutis congenita (ACC). A newborn baby at 39 weeks of gestation was consulted with a scalp and cranial defect at the vertex measuring 3 × 1.5 cm. A 3-D CT scan of the skull confirmed the presence of a cranial defect at the sagittal suture and a normal brain structure. On the 13th day of life, the newborn was taken to an operating room. An autologous bone graft was harvested from adjacent normal parietal bone and grafted into the debrided congenital cranial defect. The soft tissue defect was then covered by rotation flaps. The postoperative 3-D CT scan presented a well-positioned autologous bone graft. At 1 month postoperatively, the skull contour was normal and there was no palpable defect. We report a successful surgical outcome for a congenital cranial and soft tissue defect in ACC treated using an autologous bone graft and rotation flaps. Although conservative therapy may be an alternative option, we recommend appropriate surgical reconstruction in patients at risk of potentially fatal complications.

Bone induction and defect repair by true bone ceramics incorporated with rhBMP-2 and Sr

“…3 Rabbit femoral condyle bone repair experiment. A The appearance of experimental material; B The repaired bone 6 weeks after the surgery; C Hard tissue section (HE staining, 40×); D Paraffin section (HE staining, 100×); E Paraffin section (TB staining, 100×); F Quantitative results of the histological sections (n = 3); compared with TBC&Sr, *p < 0.05; compared with TBC&BMP-2, # p < 0.05 subject to the situation of less donor sources and postoperative discomforts [9]. Calcined heterogeneous bone made of bovine cancellous bone by calcination at high temperature is an ordered crystal of bone inorganic substance, the main component of which is high purity hydroxyapatite [10], and it has calcium -phosphorus ratio and pore structure similar to the human bone [11].…”

“…In addition, it also has high requirements in bone conduction and bone inductivity [ 8 ]. Autologous bone is regarded as the “gold standard” in the study of many bone replacement materials, but it is often subject to the situation of less donor sources and postoperative discomforts [ 9 ]. Calcined heterogeneous bone made of bovine cancellous bone by calcination at high temperature is an ordered crystal of bone inorganic substance, the main component of which is high purity hydroxyapatite [ 10 ], and it has calcium - phosphorus ratio and pore structure similar to the human bone [ 11 ].…”