Reconstruction of Critical Sized Maxillofacial Defects Using Composite Allogeneic Tissue Engineering: Systematic Review of Current Literature

Ramezanzade, Shaqayeq; Aeinehvand, Mahsa; Ziaei, Heliya; Khurshid, Zohaib; Keyhan, Seied Omid; Fallahi, Hamid Reza; Melville, James C.; Saeinasab, Morvarid; Sefat, Farshid

doi:10.3390/biomimetics8020142

Cited by 5 publications

(1 citation statement)

References 40 publications

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“…For now, there have not been detailed instructions formulated that would vouch for successful living tissue replacement with no adverse effects. This narrative review provides the reader with up-to-date information and novel trends in the field of regenerative dentistry and tissue replacement therapy [9][10][11][12], including the most current utilization, applications, improvements, and methods over the last five years (2019-August 2023). To replace living tissue in the human body using biocompatible 3D-printed grafts (usually in the form of scaffolds), we need to understand numerous biological processes and interactions between native tissues, cells, and scaffolds, promote their migration towards the injured area, ensure adequate vascularization and biodegradation, etc.…”

Section: Introduction 1historical Background and Significance Of Scaf...mentioning

confidence: 99%

Evolving Strategies and Materials for Scaffold Development in Regenerative Dentistry

Gašparovič,

Jungová,

Tomášik

et al. 2024

Applied Sciences

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Regenerative dentistry has experienced remarkable advancement in recent years. The interdisciplinary discoveries in stem cell applications and scaffold design and fabrication, including novel techniques and biomaterials, have demonstrated immense potential in the field of tissue engineering and regenerative therapy. Scaffolds play a pivotal role in regenerative dentistry by facilitating tissue regeneration and restoring damaged or missing dental structures. These biocompatible and biomimetic structures serve as a temporary framework for cells to adhere, proliferate, and differentiate into functional tissues. This review provides a concise overview of the evolution of scaffold strategies in regenerative dentistry, along with a novel analysis (Bard v2.0 based on the Gemini neural network architecture) of the most commonly employed materials used for scaffold fabrication during the last 10 years. Additionally, it delves into bioprinting, stem cell colonization techniques and procedures, and outlines the prospects of regenerating a whole tooth in the future. Moreover, it discusses the optimal conditions for maximizing mesenchymal stem cell utilization and optimizing scaffold design and personalization through precise 3D bioprinting. This review highlights the recent advancements in scaffold development, particularly with the advent of 3D bioprinting technologies, and is based on a comprehensive literature search of the most influential recent publications in this field.

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Section: Introduction 1historical Background and Significance Of Scaf...mentioning

confidence: 99%

Evolving Strategies and Materials for Scaffold Development in Regenerative Dentistry

Gašparovič,

Jungová,

Tomášik

et al. 2024

Applied Sciences

View full text Add to dashboard Cite

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Reconstruction of Composite Mandible Defects Using a Cellular Bone Allograft and Soft Tissue Free Flap Coverage

Carlson,

Liebman,

Bak

et al. 2024

Craniomaxillofacial Trauma & Reconstruction

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Study Design Retrospective case series. Objective Cellular bone allografts (CBAs) contain the components of a successful bone graft with no autologous component and have been used extensively outside the head and neck. Descriptions of their utilization for mandible reconstruction are limited. We review our experience utilizing a CBA, with no autologous component, for the reconstruction of mandible defects. Methods Patients undergoing reconstruction of a composite mandible defect with a CBA, no added autologous component, within a patient-specific graft cage and soft tissue free flap coverage were retrospectively identified. Graft survival and defect management are assessed and results of post-operative imaging reported. Results Five subjects, aged 23–56 years, underwent reconstruction of mandible defects with the described technique. Defects resulted from gunshot wounds in 4 patients and the composite resection of a low-grade malignancy in one. The defect was definitively managed in 4 subjects, 3 of which had post-operative imaging demonstrating bone formation. The fifth experienced graft failure after developing an orocutaneous fistula and was successful salvaged with an osteocutaneous fibula free flap. Conclusions Our early experience is promising that a CBA, with no autologous component, and soft tissue free flap coverage can be used for the reconstruction of composite mandible defects in select patients.

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Injectable MXene/Ag-HA composite hydrogel for enhanced alveolar bone healing and mechanistic study

Li,

Fan,

Guan

et al. 2024

Front. Bioeng. Biotechnol.

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IntroductionAlveolar bone defects pose significant challenges in dentistry. Due to the complexity of alveolar bone anatomy and insufficient repair mechanisms, large bone defects are difficult for the body to heal naturally. Clinical treatment typically involves the use of bone substitute materials. However, current substitutes often suffer from limitations such as insufficient osteoinductivity, rapid degradation, inflammatory responses, and poor mechanical properties. Additionally, the irregular morphology of alveolar bone defects complicates the application of solid bone substitutes, potentially leading to secondary damage at the repair site.MethodsTo address these challenges, this study introduces an innovative approach by integrating MXene nanomaterials into Ag-HA/GelMA hydrogels to create an injectable MXene/Ag-HA composite hydrogel. MXene nanomaterials are renowned for their excellent biocompatibility, antibacterial properties, and mechanical strength.ResultsThe results indicate that the MXene/Ag-HA composite hydrogel exhibits satisfactory mechanical and biological properties. Specifically, it demonstrates excellent antibacterial, antioxidant, and osteogenic activities. Gene expression analysis further reveals that the MXene composite hydrogel promotes osteogenesis by regulating the expression of Dmp1 and Dusp1.DiscussionThe findings of this study suggest that the MXene/Ag-HA composite hydrogel is a promising candidate for alveolar bone repair and regeneration. The integration of MXene nanomaterials into the hydrogel enhances its mechanical and biological properties, making it well-suited for the treatment of irregular alveolar bone defects. Furthermore, the study underscores the vast potential of MXene nanomaterials in the biomedical field, hinting at potential applications beyond alveolar bone repair.

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Reconstruction of Critical Sized Maxillofacial Defects Using Composite Allogeneic Tissue Engineering: Systematic Review of Current Literature

Cited by 5 publications

References 40 publications

Evolving Strategies and Materials for Scaffold Development in Regenerative Dentistry

Evolving Strategies and Materials for Scaffold Development in Regenerative Dentistry

Reconstruction of Composite Mandible Defects Using a Cellular Bone Allograft and Soft Tissue Free Flap Coverage

Injectable MXene/Ag-HA composite hydrogel for enhanced alveolar bone healing and mechanistic study

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