Reconstruction of frontal defects with calvarial grafts

Dova, Stamatia; Karkos, Petros D.; Constantinidis, J.

doi:10.4193/rhin17.185

Cited by 7 publications

(3 citation statements)

References 20 publications

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“…Cranioplasty through titanium, ceramic, or plastic implants is among the most frequently employed strategies, and most invariably requires a two-stage surgery [ 120 ]. Autogenous calvarial grafts [ 121 ] or free flaps [ 122 , 123 , 124 ] have also been described to reconstruct defects of the frontal bone.…”

Section: Treatmentmentioning

confidence: 99%

Sinonasal Squamous Cell Carcinoma, a Narrative Reappraisal of the Current Evidence

Ferrari

Taboni

Carobbio

et al. 2021

Cancers

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Sinonasal squamous cell carcinoma is a rare tumor affecting the nasal cavity and paranasal sinuses. Several aspects of this disease, ranging from epidemiology to biology, pathology, diagnosis, staging, treatment, and post-treatment surveillance are controversial, and consensus on how to manage this sinonasal cancer is lacking. A narrative literature review was performed to summarize the current evidence and provide the reader with available data supporting the decision-making process in patients affected by sinonasal squamous cell carcinoma, alongside the authors’ personal opinion on the unsolved issues of this tumor. The review has highlighted several advances in molecular definition of epithelial cancers of the sinonasal tract. Surgery represents the pivot of treatment and is performed through an endoscopic transnasal approach whenever feasible. Open surgery is required for a large proportion of cases. Reconstruction of the defect follows principles of skull base and cranio-maxillo-facial reconstruction. Chemotherapy is given as neoadjuvant treatment or concomitantly to radiotherapy. Photon-based radiation therapy has a crucial role in the adjuvant setting. Particle therapy is providing promising results. Management of the neck should be planned based on the presence of clinically appreciable metastases, primary tumor extension, and need for recipient vessels. Biotherapy and immunotherapy are still underexplored therapeutical modalities.

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Section: Treatmentmentioning

confidence: 99%

Sinonasal Squamous Cell Carcinoma, a Narrative Reappraisal of the Current Evidence

Ferrari

Taboni

Carobbio

et al. 2021

Cancers

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“…The use of mySinusitisCoach facilitates evaluation of patient reported outcome measures and allows not only tailoring of treatment to the level of control of the disease but will also allow us in future to collect longitudinal data about our patient care. This issue of the journal is full of very interesting papers about different subjects; from cystic fibrosis (49,50) to autonomic disfunction (51) , and from calvarian bone for the reconstruction of frontal defects (52) to upregulation of TRPV1 expression in chronic rhinosinusitis with nasal polyps (53) .…”

Section: Delivering Better Results For Patients Through Core Outcomesmentioning

confidence: 99%

Delivering better results for patients through core outcomes, measuring evidence and patient participation

Fokkens

2018

Rhin

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Nasal obstruction is one of the most frequent and bothersome symptoms in rhinosinal disease. Although we are able to measure nasal airflow, the correlation between the feeling of nasal obstruction and objective measurements has been shown to be average at most. A significant proportion of the European population has a more or less deviated nasal septum and deviated septa have received a lot of attention from otorhinolaryngologists. In sharp contrast is the amount of hard evidence concerning septoplasty with or without turbinate surgery.

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“…On the other hand, radiological and mechanical techniques have been used for structural and functional evaluations (50)(51)(52). Different bone graft materials are currently available for regeneration of bone defects in oral and maxillofacial surgery, such as the closure of osteotomy openings and alveolar increment (53)(54)(55)(56)(57). Synthetic bone graft materials are available in intra-bone defects, orthognathic surgery, facial bone defects, and maxillary sinus ground (54,(58)(59)(60)(61)(62)(63).…”

Section: Discussionmentioning

confidence: 99%

Effects of alloplastic graft material combined with a topical ozone application on calvarial bone defects in rats

et al. 2020

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Background:The present study presents the evaluation of the damage in the bone tissue resulting from a calvarial defect in rats and the efficiency of exposure to an ozone application with an alloplastic bone graft on the calvarial bone damage. Materials and methods:Wistar male rats (n = 56) were divided into four groups: a control group (n = 14), defect and ozone group (n = 14), defect and graft group (n = 14), and defect, graft, and ozone group (n = 14). Under anaesthesia, a circular full-thickness bone defect was created in all groups, and the experimental groups were further divided into two sub-groups, with seven rats in each group sacrificed at the end of the 4 th and 8 th weeks. Bone samples were dissected, fixed in 10% formalin solution, and decalcified with 5% ethylene-diaminetetraacetic acid (EDTA). After the routine follow-up on tissues, immunostaining of osteopontin and osteonectin antibodies was applied to sections and observed under a light microscope. Results:The control group exhibited osteopontin and osteonectin expression in fibroblasts and inflammatory cells at the end of the 4 th week with an acceleration at the 8 th week. Ozone administration elucidated new trabecular bone formation by increasing osteoblastic activity.Lastly, our observations underscore that a combination of allograft and ozone application increased the osteoblast, osteocyte, and bone matrix development at the 4 th and 8 th weeks. Conclusions:Exposure to an ozone application with an alloplastic bone graft on calvarial bone damage may induce osteoblastic activity, matrix development, mature bone cell formation, and new bone formation in rats.

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Reconstruction of frontal defects with calvarial grafts

Abstract: Our results indicate that calvarial bone graft is an appropriate material to use in anterior frontal sinus reconstruction.

Cited by 7 publications

References 20 publications

Sinonasal Squamous Cell Carcinoma, a Narrative Reappraisal of the Current Evidence

Sinonasal Squamous Cell Carcinoma, a Narrative Reappraisal of the Current Evidence

Delivering better results for patients through core outcomes, measuring evidence and patient participation

Effects of alloplastic graft material combined with a topical ozone application on calvarial bone defects in rats

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