Reconstruction of gluteal defects related to Nicolau Syndrome secondary to intramuscular injection of diclofenac sodium with negative pressure wound therapy followed by skin graft.

Kokaçya, Ömer; Tabakan, İbrahim; Gencel, Eyüphan; Eser, Cengiz

doi:10.17546/msd.46783

Cited by 1 publication

(2 citation statements)

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“…The chance‐adjusted agreement between the two investigators on the application of the inclusion and exclusion criteria was 0.88. A total of 45 eligible reports 6‐50 published between 1996 and 2019 in English (N = 44) or Spanish (N = 1) were identified. The reports were primarily (N = 41, 91%) from Europe (Turkey, N = 17; Italy, N = 4; Belgium, N = 1; Germany, N = 1; Switzerland, N = 1) and Asia (India, N = 9; South Korea, N = 5; China, N = 1; Israel, N = 1; Qatar, N = 1).…”

Section: Resultsmentioning

confidence: 99%

“…The aforementioned 45 reports included 62 previously healthy subjects (40 females and 22 males aged from 13 to 81, median 57 years) with Nicolau syndrome occurring after intramuscular 6‐11,13‐50 or local 12 injection of a non‐steroidal anti‐inflammatory drug, as shown in Table 1. The vast majority of cases (N = 53; 85%) occurred following administration of diclofenac.…”

Section: Resultsmentioning

confidence: 99%

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Nicolau syndrome caused by non‐steroidal anti‐inflammatory drugs: Systematic literature review

Lardelli

Jermini

Milani

et al. 2020

Int. J. Clin. Pract.

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Aim Intramuscular or, more rarely, local drug injection is occasionally followed by immediate local pain, livedoid skin lesions and, some days later, the development of ischemic lesions. This very uncommon but potentially severe reaction, termed Nicolau syndrome, is traditionally associated with bismuth and β‐lactam antimicrobials. The aim of this report was to review the literature associating Nicolau syndrome with the administration of non‐steroidal anti‐inflammatory drugs. Methods The National Library, Excerpta Medica, Web of Science and Cochrane library databases were used. Results Sixty‐two cases (40 females and 22 males aged from 13 to 81, median 57 years) of Nicolau syndrome were published after 1992. Fifty‐three cases occurred after diclofenac. The remaining nine cases were associated with ketoprofen (N = 2), ketorolac (N = 2), phenylbutazone (N = 2), etofenamate (N = 1), ibuprofen (N = 1) and piroxicam (N = 1). Conclusion Although Nicolau syndrome is extremely uncommon, physicians must be aware of this complication after intramuscular administration of non‐steroidal anti‐inflammatory drugs and should avoid unnecessary injections.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%