Reconstruction of large rotator-cuff tears with acellular dermal matrix grafts in rats

Ide, Junji; Kikukawa, Kenshi; Hirose, Jun; Iyama, Ken Ichi; Sakamoto, Hidetoshi; Mizuta, Hiroshi

doi:10.1016/j.jse.2008.09.004

Cited by 84 publications

(63 citation statements)

References 25 publications

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“…rotator cuff tendon of a normal rat. Ide et al [22] performed biomechanical testing in these rats and showed that the graft group had a greater mean ultimate force to failure. The other animal model tests done by Song et al [23] on sheep tendo Achilles repairs have shown that Graft Jacket® enhances the tendon strength in comparison with non-augmented repairs.…”

Section: Discussionmentioning

confidence: 99%

Surgical repair of hip abductors. A new technique using Graft Jacket® allograft acellular human dermal matrix

Rao

Kamal

Vafaye

et al. 2012

International Orthopaedics (SICOT)

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Purpose Avulsion of the abductors from the hip can be an infrequent but debilitating complication after total hip arthroplasty performed through a trans-gluteal approach. This can result in intractable pain, limp, Trendelenberg lurch and instability of the hip. There have been various methods described for repairing or reconstruction of this abductor muscle complex including direct trans-osseous repair, muscle transfers, muscle and tendon sling, bone tendon allograft reconstruction and endoscopic repair techniques. Methods In a prospective study at our institution we evaluated the results of a surgical technique in 12 patients using a transosseous repair of gluteus medius and minimus insertions augmented by a Graft Jacket® allograft acellular human dermal matrix (Graft Jacket®; Wright Medical Technology, Arlington, TN) over the anterior and anterolateral aspects of the greater trochanter. Diagnosis of hip abductor avulsions was made by evaluation of the history of presenting complaint, clinical examination and confirmed by ultrasound or MRI scans.

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Section: Discussionmentioning

confidence: 99%

Surgical repair of hip abductors. A new technique using Graft Jacket® allograft acellular human dermal matrix

Rao

Kamal

Vafaye

et al. 2012

International Orthopaedics (SICOT)

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“…39 Hence, the rat model lends itself particularly well to studying regenerative strategies for tendon-to-bone repair that are biologically based as the effectiveness of these types of approaches, for example, growth factor therapy, depend to a large extent on maintaining an intact tendonbone repair interface. Recently, the rat has also been used to study the use of scaffold devices for rotator cuff repair augmentation 40 or interposition grafting across a large rotator cuff defect, [41][42][43] which is a regenerative strategy that fundamentally targets joint closure and not anatomic (mechanical) repair.…”

mentioning

confidence: 99%

“…34,35,39 The rat tolerates bilateral shoulder surgery (e.g., Refs. 31,40,43 ), which offers the experimental advantage of having a paired control. As well, the rat model has been used to investigate the pervasive clinical problems of chronic rotator cuff repair [44][45][46][47][48][49] and two tendon tears.…”

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confidence: 99%

Preclinical Models for Translating Regenerative Medicine Therapies for Rotator Cuff Repair

Derwin

Baker

Iannotti

et al. 2010

Tissue Engineering Part B: Reviews

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Despite improvements in the understanding of rotator cuff pathology and advances in surgical treatment options, repairs of chronic rotator cuff tears often re-tear or fail to heal after surgery. Hence, there is a critical need for new regenerative repair strategies that provide effective mechanical reinforcement of rotator cuff repair as well as stimulate and enhance the patient's intrinsic healing potential. This article will discuss and identify appropriate models for translating regenerative medicine therapies for rotator cuff repair. Animal models are an essential part of the research and development pathway; however, no one animal model reproduces all of the features of the human injury condition. The rat shoulder is considered the most appropriate model to investigate the initial safety, mechanism, and efficacy of biologic treatments aimed to enhance tendon-to-bone repair. Whereas large animal models are considered more appropriate to investigate the surgical methods, safety and efficacy of the mechanical-or combination biologic=mechanical-strategies are ultimately needed for treating human patients. The human cadaver shoulder model, performed using standard-of-care repair techniques, is considered the best for establishing the surgical techniques and mechanical efficacy of various repair strategies at time zero. While preclinical models provide a critical aspect of the translational pathway for engineered tissues, controlled clinical trials and postmarketing surveillance are also needed to define the efficacy, proper indications, and the method of application for each new regenerative medicine strategy.

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“…Ide et al [28] found rotator cuff tears repaired with allogenic ECM (GraftJacket 1 ) augmentation had higher tendon maturing scores than an untreated control defect group, demonstrated greater mean ultimate force to failure than the defect group, and performed better histologically and mechanically at every point in the study. Cadaveric studies comparing allogenic-augmented rotator cuff repairs (GraftJacket 1 ) to rotator cuff repairs without augmentation demonstrated that the use of human dermal allograft increased the strength of the repaired tendon; the mean failure strengths were 325 ± 74 N with allogenic ECM and 273 ± 116 N without allogenic ECM [3].…”

Section: Ecm Augmentationmentioning

confidence: 99%

Strategies in Biologic Augmentation of Rotator Cuff Repair: A Review

Cheung

Silverio

Sperling

2010

Clinical Orthopaedics &Amp; Related Research

147

103

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Background Degenerative rotator cuff tears are increasing with the aging population, and healing is not uniform after surgery. Rotator cuffs may show improved healing when biologic factors are added during surgery. Questions/purposes We asked: (1) What cellular processes are involved in normal bone-to-tendon healing? (2) What approaches are being developed in tendon augmentation? (3) What approaches are being developed with the addition of growth factors? Methods We reviewed research in relating to biologic augmentation and cellular processes involved in rotator cuff repair, focusing on animal models of rotator cuff repair and nonrandomized human trials. Results Regular bone-to-tendon healing forms a fibrous junction between tendon and bone that is distinct from the original bone-to-tendon junction. Tendon augmentation with cellular components serves as scaffolding for fibroblastic cells and a possible source of growth factors and fibroblastic cells. Extracellular matrices provide a scaffold for incoming fibroblastic cells, although current research does not conclusively confirm which if any of these scaffolds enhance repair owing in part to intermanufacturer variations and the limited human research. Growth factors and platelet-rich-plasma are established in other fields of research and may enhance repair but have not been rigorously tested. Conclusions There is potential application of biologic augmentation to improve healing after rotator cuff repair. However, research in this field is still inconclusive and has not been sufficiently demonstrated to merit regular clinical use. Future human trials can elucidate the use of biologic augmentation in rotator cuff repairs.

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Reconstruction of large rotator-cuff tears with acellular dermal matrix grafts in rats

Cited by 84 publications

References 25 publications

Surgical repair of hip abductors. A new technique using Graft Jacket® allograft acellular human dermal matrix

Surgical repair of hip abductors. A new technique using Graft Jacket® allograft acellular human dermal matrix

Preclinical Models for Translating Regenerative Medicine Therapies for Rotator Cuff Repair

Strategies in Biologic Augmentation of Rotator Cuff Repair: A Review

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