Reconstruction of Sphenoid Wing Dysplasia in Neurofibromatosis Type-1 Patients: An Evolving Technique

Relationships between severities of dermatological, neurological, and bone manifestations in neurofibromatosis type 1

“…The present study comprehensively showed correlations between each severity stage in main NF1‐related manifestations. The correlations may be at least partially associated with the fact that (i) plexiform neurofibromas sometimes compress cranial nerves and/or peripheral nerve roots at the vertebral column, resulting in neurological problems; 5 (ii) plexiform neurofibroma affecting the extremities may concomitantly present with bone manifestations; 6 (iii) sphenoid wing dysplasia occasionally results in severe ophthalmological problems through plexiform neurofibroma progression and/or intraorbital meningoencephalocele 7 . Correlations were also detected between patient age and severity.…”