Reconstruction of the edentulous mandible with fresh frozen bone grafts and implants: a 4-year report of a prospective clinical study

Abstract

Allogen bones from tissue bank are often used in dentistry although the data analyzing the long-term success in mandible are scarce. This study evaluated by computed tomography scans (CTS) the bone resorption around the implants installed on fresh frozen bone (FFB) previously grafted, after 4 years of occlusal rehabilitation. Six subjects were grafted with blocks in posterior mandible using FFB. After 6 months, 27 implants were placed and after further 4 months the prostheses were delivered. Following 4 years of the final rehabilitation procedures, another CTS was done in order to measure the resorption in periimplant bone crest at the proximal implant surfaces. It was observed a 100 % survival rate of the implants after 4 years of the fixture installation. The marginal bone resorption after 48 months was 2.82 ± 1.63 mm and no statistical significant difference was observed along the region where the implants were fixed when compared with the interimplantar space. In addition there was no significant correlation regarding the length of the implant used and the amount of marginal bone resorption. The conclusion is that grafted areas with FFB are suitable to implant installation in the posterior mandible.

Corticocancellous fresh‐frozen allograft bone blocks for augmenting atrophied posterior mandibles in humans

“…We obtained an implant placement success rate of 96.6% in an evaluation period of 15.3-28.7 months. Other studies have shown a similar high success rate of osseointegration, varying from 95.3 to 100% (Holmquist et al 2008;Contar et al 2009;Morelli et al 2009;Nissan et al 2011a,b;Novell et al 2012;Pimentel et al 2014). However, among those previous studies, some (Holmquist et al 2008;Contar et al 2009;Novell et al 2012) studies used this technique on the maxilla; thus, it is difficult to make a direct comparison, as maxillary bone has greater vascularization and the FFB has a greater chance to integrate at the recipient site.…”

“…Magnification, 109. Macedo et al 2012;Chiapasco et al 2013;Pimentel et al 2014). This study was designed to evaluate whether corticomedullary grafts in FFB blocks could be used for bone augmentation and maintenance of graft volume in atrophied posterior human mandibles.…”

“…Recent studies have shown that a freezedried bone allograft (FDBA) is a viable alternative for reconstructing atrophied posterior mandible bone (Nissan et al 2011a,b). However, few studies have assessed the use of fresh-frozen bone (FFB) blocks in the posterior mandible (Macedo et al 2012;Pimentel et al 2014).…”

Presence of Cells in Fresh-Frozen Allogeneic Bone Grafts from Different Tissue Banks

“…Allogeneic bone is considered a second line treatment option for grafting, due mainly to its osteoconductive properties (15) and high implant survival rates (16,17). The antigenicity and immune response associated with allogenic bone grafts remain poorly understood (8,18) and so, largely controversial.…”

Uso de osso alógeno córtico-medular fresco congelado em bloco para aumento posterior de mandíbula atrófica: estudo clínico, histológico e histomorfométrico em humanos

“…O risco possível de transmissão de doenças é praticamente nulo devido às técnicas atuais de captação, rastreamento, processamento e quarentena. Após um período mínimo de armazenamento de 6 meses a -80ºC, o tecido ósseo somente será liberado, caso não haja contraindicações oriundas de possíveis resultados da rastreabilidade (Dodd et al, 1988;Tomford, 2000;Giannoudis et al, 2005;Heyligers e Klein-Nulend, 2005;Pimentel et al, 2014). Outro fator importante é o resfriamento do osso alógeno humano a uma temperatura menor que -20ºC que diminui, consideravelmente, a antigenicidade (Dodd et al, 1988;Contar et al, 2009).…”