Reconstruction of the Mandible Using Bioresorbable Poly[l-Lactide]mesh and Autogenic Particulate Cancellous Bone and Marrow and Application of Dental Implant

Kinoshita, Yukihiko; Yokoya, Shigetoshi; Mizutani, Naritaka; Mizunuma, Hideyuki; Inoue, Satoru; Amagasa, Teruo; Kudo, Keigo; Nagayama, Masaru; Okabe, Susumu; Totsuka, Yasunori; Furuta, Isao

doi:10.5981/jjhnc1974.26.525

Cited by 2 publications

(3 citation statements)

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“…The absorbable membranes used were either experimental materials [57,133], similar to the ones used in the animal studies, or commercially available material manufactured for other purposes [13,134]. …”

Section: Introductionmentioning

confidence: 99%

“…Tables 6 and 7 summarize the clinical studies, in which absorbable membranes were used for bone regeneration of the mandible and the long bones, respectively. The absorbable membranes used were either experimental materials [ 57 , 133 ], similar to the ones used in the animal studies, or commercially available material manufactured for other purposes [ 13 , 134 ].…”

Section: Introductionmentioning

confidence: 99%

“…There are only three studies in humans where bioabsorbable membranes have been used for reconstruction of segmental or large mandibular bone defects using bioresorbable PLLA barrier membrane (mesh) in combination with autologous bone graft (Table 6 ) [ 33 , 57 , 133 ]. The majority of the bone defects were secondary to benign or malignant tumors of the mandible, but other causes included infection, alveolar atrophy and trauma.…”

Section: Introductionmentioning

confidence: 99%

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The role of barrier membranes for guided bone regeneration and restoration of large bone defects: current experimental and clinical evidence

Dimitriou

Mataliotakis

Calori

et al. 2012

BMC Med

310

280

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Treatment of large bone defects represents a great challenge in orthopedic and craniomaxillofacial surgery. Although there are several methods for bone reconstruction, they all have specific indications and limitations. The concept of using barrier membranes for restoration of bone defects has been developed in an effort to simplify their treatment by offering a sinlge-staged procedure. Research on this field of bone regeneration is ongoing, with evidence being mainly attained from preclinical studies. The purpose of this review is to summarize the current experimental and clinical evidence on the use of barrier membranes for restoration of bone defects in maxillofacial and orthopedic surgery. Although there are a few promising preliminary human studies, before clinical applications can be recommended, future research should aim to establish the 'ideal' barrier membrane and delineate the need for additional bone grafting materials aiming to 'mimic' or even accelerate the normal process of bone formation. Reproducible results and long-term observations with barrier membranes in animal studies, and particularly in large animal models, are required as well as well-designed clinical studies to evaluate their safety, efficacy and cost-effectiveness.

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