Twelve patients, who previously had surgery for peptic ulcer, underwent a Roux-en-Y procedure for the treatment of a combination of severe symptoms. The original operation was truncal vagotomy with pyloroplasty in 7 and Billroth II gastrectomy in 5 patients. In those 5 patients a truncal vagotomy was added. Enterogastric reflux (EGR) was documented preoperatively with milk-EHIDA scintigraphy in all of them, and 8 patients had dumping syndrome with a positive dumping provocation test (DPT). Recurrence of ulceration was found preoperatively in 4 patients. All patients were classified as Visick III or IV. At an average follow-up of 2.5 years, all patients but 1 were classified as Visick I or II. DPT was negative and EGR was almost totally abolished in all subjects. Only 3 patients had mild symptoms of gastric stasis, although gastric emptying of solids as evaluated with gastric scintigraphy of a labelled test meal was found significantly delayed in all patients as compared to healthy volunteers. Gastrectomy with Roux-en-Y gastrojejunostomy is an effective procedure for the treatment of enterogastric reflux, dumping syndrome and recurrent ulceration, especially when these problems coexist in the same patient.