Reconstruction of Tibial Plateau Fracture Malunion in the Setting of a Large Cartilage Defect in an Adolescent

Abstract

Case: An 18-year-old adolescent boy presented with knee pain and stiffness secondary to tibial plateau valgus malunion and osteochondral defect, 8 months after initial injury/fixation. We opted for a novel technique that reconstructs the convex lateral tibial plateau by using osteotomy and an osteochondral autograft harvested from the lateral aspect of the ipsilateral femoral condyle. Conclusion: The reported novel reconstruction technique is inexpensive, achievable with routine techniques, and demonstrated a favorable short-term outcome. At 3 years of follow-up, the patient had excellent, asymptomatic, left knee mobility and function with radiographic evidence of mild posttraumatic arthritis despite normal knee alignment.

Noninvasive and Microinvasive Nanoscale Drug Delivery Platforms for Hard Tissue Engineering

“…The physical limitations are related to the treatment of different fractures, which inevitably infer a surgical approach. In addition to naturally occurring fractures that have occurred because of different incidents, , the physical limitation to the use of nanoscale drug delivery systems also includes secondary bone tissue conditions , (those directly connected with surgical outcomes) and malunion types of fracture (abnormal healing of a broken bone). , Nevertheless, nanoscale-based formulations and platforms have already been studied postsurgically − to cope with some of these physical limitations. In rat models, researchers , have achieved promotion of hard tissue formation after a defect was induced, which marks a promising position of these systems to be applied to humans.…”