Reconstructive Options for Osteonecrosis of the Femoral Head

Ivankovich, Daniel Anthony; Rosenberg, Aaron G.; Malamis, A.

doi:10.1097/00013611-200103000-00009

Cited by 6 publications

(5 citation statements)

References 37 publications

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“…It has been stated that the joint remobilization usually lead to hyaline cartilage differentiation in long term period. [18] Radiographic finding were supported the result of histological assessment of osseous incorporation of graft with subchondral bone with secondary femoral head changes [5,[20][21][22] . The results showed that the foetal skull bone before complete ossification placed in suitable environment easily can reorient itself into chondrocytes and cartilagenous tissues in weightbearing articualr surface.…”

Section: Discussionmentioning

confidence: 59%

Gross and Histomorphological Studies of Femoral Head Resurfacing in Dog

Sharifi¹,

Razaei²,

Savadkouhi³

et al. 2006

American J. of Animal and Veterinary Sciences

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The foetal skull bone as a biological graft was investigated. This study was conducted on Fifteen adult mixed - breed normal dogs 12 to 24 months with weighing 21.4=3.6 Kg .Dogs were randomly divided into 3 groups of 5 animals each. The foetal skull bone of 45 days old was collected from one pregnant bitch via cesarean method. The right femoral head cartilage was removed completely in all dogs of 3 groups.. Group I acted as control one, whereas in II group, resurfacing was done by using foetal skull bone which was fixed by using 0.8 mm cerclage wire in criss-cross fashion, but in III group, it was done similar to II group and the hip joint additionally was fixed by using 2 mm steinmenn pin.The clinical observations was made accordingly for 60 days in all groups. The gross changes of femoral head in group I & II were quite smooth and slippy, but in III group were uneven and rough due to secondary changes and ankylosis, but on micropscopic interpertation there was a remarkable compatibility of the graft with femoral head.The reconstruction of articular cartilage was faster in group II and even group III animals than group I animals. There was single row of chondrocyte in scatter area of samples in group . The complete and uniform hyaline cartilage in group II and fibro - cartilage and mixture of connective tissues in group III animals were observed. The results indicated that the foetal skull bone due to its pleuripotent calvarium easily can orient itself into the chondrocytes and cartilagenous tissues in articular surface of the hip joint, if there is suitable enviroment before complete ossification,so that normal joint motion could expect

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Section: Discussionmentioning

confidence: 59%

Gross and Histomorphological Studies of Femoral Head Resurfacing in Dog

Sharifi¹,

Razaei²,

Savadkouhi³

et al. 2006

American J. of Animal and Veterinary Sciences

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show abstract

“…THA has excellent clinical results for pain relief and functional improvement, but these reconstructive arthroplasties in young patients can be problematic, as they are often associated with early failure from loosening and other complications [48][49][50][51] . Femoral resurfacing can be used in younger patients with osteonecrosis involving less than one third of the femoral head, and this arthroplasty option has been studied and used more outside of the United States.…”

Section: Current Treatment Optionsmentioning

confidence: 99%

“…Femoral resurfacing can be used in younger patients with osteonecrosis involving less than one third of the femoral head, and this arthroplasty option has been studied and used more outside of the United States. Technical issues with these implants have been associated in the past with femoral neck fracture, high failure rate, and conversion to THA [48,52] . Newer designs and uncemented implants have yielded more favorable results, but other complications such as ionic metal wear in metal-on- metal implants can still occur [53] .…”

Section: Current Treatment Optionsmentioning

confidence: 99%

“…Newer designs and uncemented implants have yielded more favorable results, but other complications such as ionic metal wear in metal-on- metal implants can still occur [53] . Hemiarthroplasty with unipolar or bipolar implants have been utilized but by design do not address pathology at the acetabular surface in late-stage osteonecrosis and are also associated with wear, loosening, groin pain, and conversion to THA [48] ; therefore hemiarthroplasty is not recommended.…”

Section: Current Treatment Optionsmentioning

confidence: 99%

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Osteonecrosis of the femoral head: An update in year 2012

Kaushik

Das²,

Cui³

2012

WJO

138

118

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Osteonecrosis is a phenomenon involving disruption to the vascular supply to the femoral head, resulting in articular surface collapse and eventual osteoarthritis. Although alcoholism, steroid use, and hip trauma remain the most common causes, several other etiologies for osteonecrosis have been identified. Basic science research utilizing animal models and stem cell applications continue to further elucidate the pathophysiology of osteonecrosis and promise novel treatment options in the future. Clinical studies evaluating modern joint-sparing procedures have demonstrated significant improvements in outcomes, but hip arthroplasty is still the most common procedure performed in these affected younger adults. Further advances in joint-preserving procedures are required and will be widely studied in the coming decade.

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“…To date, theories of metabolic disturbance, osteoporosis, intraosseous hypertension, intracellular coagulation and cytotoxicity have been hypothesized to explain its pathogenesis, but the underlying pathological change in ONFH is microcirculation disturbance ( 1 , 2 ). Furthermore, the treatment of ONFH remains a controversial challenge as no safe or effective prevention and treatment methods have been identified ( 3 – 5 ).…”

Section: Introductionmentioning

confidence: 99%

Cajan leaf combined with bone marrow-derived mesenchymal stem cells for the treatment of osteonecrosis of the femoral head

Shi

Sun

Yin

et al. 2014

Experimental and Therapeutic Medicine

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The aim of the present study was to observe the curative effect of traditional Chinese cajan leaves, combined with administration of bone marrow-derived mesenchymal stem cells (BMSCs), on osteonecrosis of the femoral head (ONFH) in rats and to investigate the underlying mechanisms. A total of 40 rat ONFH models were established through liquid nitrogen freezing and were subsequently divided into groups: A, control; B, treated with cajan leaf; C, treated with BMSCs and D, treated with cajan leaf combined with BMSCs. Samples were obtained 30 days following treatment, and immunohistochemical staining of vascular endothelial growth factor (VEGF) and image analysis were performed. Chondrocytes and vascular endothelial cells were stained as a result of immunohistochemical staining and group D exhibited markedly deeper staining, and a significantly larger number of stained cells, compared with group A. Thus, in the present study, cajan leaf combined with BMSCs was shown to promote VEGF expression and improve ONFH repair.

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Reconstructive Options for Osteonecrosis of the Femoral Head

Cited by 6 publications

References 37 publications

Gross and Histomorphological Studies of Femoral Head Resurfacing in Dog

Gross and Histomorphological Studies of Femoral Head Resurfacing in Dog

Osteonecrosis of the femoral head: An update in year 2012

Cajan leaf combined with bone marrow-derived mesenchymal stem cells for the treatment of osteonecrosis of the femoral head

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