Record-high incidence of Type I (insulin-dependent) diabetes mellitus in Finnish children

Tuomilehto, Jaakko; Karvonen, Marjatta; Pitkäniemi, Janne; Virtala, Esa; Kohtamäki, Kimmo; Toivanen, Liisa; Tuomilehto‐Wolf, Eva

doi:10.1007/s001250051212

Cited by 134 publications

(98 citation statements)

References 30 publications

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“…An obvious explanation, although difficult to prove, would be the influence of an exogenous factor triggering the islet cell destruction in genetically prone children. As there was not such an impressive obvious change in the daily lifestyle or eating behaviour in the past ten years than before, other triggers like viral infections of any kind or vaccination programme modifications as discussed elsewhere [4,7,8] are at present speculative.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Type I diabetes mellitus in Switzerland: steep rise in incidence in under 5 year old children in the past decade

et al. 2001

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Section: Discussionmentioning

confidence: 99%

Epidemiology of Type I diabetes mellitus in Switzerland: steep rise in incidence in under 5 year old children in the past decade

et al. 2001

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“…The analysed patients represented a carefully characterised study sample with a genetically homogeneous background from the Finnish population, which has the highest incidence rate of type 1 diabetes in the world [12], and the genotyping and statistical methods used in this study represent the state of the art. The SNP coverage can be considered sufficient to detect haplotype variation in the NPHS2 and ACTN4 genes.…”

Section: Discussionmentioning

confidence: 99%

Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy

et al. 2007

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Aims/hypothesis The slit diaphragm is an adhesion and signalling protein complex linking the interdigitating podocyte foot processes in the kidney glomerulus, and mutations in slit diaphragm-associated genes result in severe proteinuria. Here we report a genetic association analysis of four slit diaphragm genes, LRRC7, KIRREL, NPHS2 and ACTN4, in a Finnish diabetic nephropathy cohort. Materials and methods A total of 40 single nucleotide polymorphisms (SNPs) were genotyped in 1103 patients with type 1 diabetes. The patients were classified according to their renal status, and the genotype data were analysed in a cross-sectional case-control setting. To confirm positive associations, four SNPs were genotyped in 1,025 additional patients with type 1 diabetes. Results No associations with diabetic nephropathy were observed for any of the analysed SNPs. The SNPs were not associated with the time from the onset of diabetes to the diagnosis of nephropathy or with glomerular filtration rate or AER as quantitative variables. In a sex-specific sub-analysis, the variants rs979972 and rs749701 in the first intron of ACTN4 were nominally associated with diabetic nephropathy in females, with odds ratios of 1.81 (95% CI 1.18-2.79, p=0.007) and 1.93 (95% CI 1.26-2.96, p=0.003) respectively. Conclusions/interpretation Our study has not found any evidence that common variants in LRRC7, KIRREL, NPHS2 and ACTN4 contribute to susceptibility to diabetic nephropathy in Finnish patients with type 1 diabetes.

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“…Thus, all newly diagnosed subjects have been registered since 1987 [30]. The case ascertainment is virtually 100 % complete [2,3,30].…”

Section: Methodsmentioning

confidence: 99%

Bayesian analysis of geographical variation in the incidence of Type I diabetes in Finland

Rytkönen¹,

Ranta

Tuomilehto³

et al. 2001

Diabetologia

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Record-high incidence of Type I (insulin-dependent) diabetes mellitus in Finnish children

Cited by 134 publications

References 30 publications

Epidemiology of Type I diabetes mellitus in Switzerland: steep rise in incidence in under 5 year old children in the past decade

Epidemiology of Type I diabetes mellitus in Switzerland: steep rise in incidence in under 5 year old children in the past decade

Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy

Bayesian analysis of geographical variation in the incidence of Type I diabetes in Finland

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