Objective: To evaluate the impact of cardiovascular disease (CVD) on mortality and readmission risk in patients with dementia.Methods: Prospective hospital-based cohort of 59 194 patients with dementia admitted to hospital or visiting a day-clinic between 2000 and 2010. Patients were divided in those with and without a history of CVD (ie, previous admission for CVD; coronary heart disease, heart failure, stroke, atrial fibrillation, or other CVD). Absolute mortality risks (ARs), median survival times, and hazard ratios (adjusted for age, sex, and comorbidity) were calculated.Results: Three-year ARs and HRs were higher, and survival times were shorter among patients visiting a day-clinic with a history of CVD than in those without.The differences were less pronounced for inpatients. Readmission risk was further increased in the presence of CVD in both day clinic and inpatients.Conclusion: Clinicians need to be more aware of worse prognosis of the population with CVD and dementia.