Record Ultralarge‐Pores, Low Density Three‐Dimensional Covalent Organic Framework for Controlled Drug Delivery**

Abstract

The unique structural characteristics of three‐dimensional (3D) covalent organic frameworks (COFs) like high surface areas, interconnected pore system and readily accessible active sites render them promising platforms for a wide set of functional applications. Albeit promising, the reticular construction of 3D COFs with large pores is a very demanding task owing to the formation of interpenetrated frameworks. Herein we report the designed synthesis of a 3D non‐interpenetrated stp net COF, namely TUS‐64, with the largest pore size of all 3D COFs (47 Å) and record‐low density (0.106 g cm−3) by reticulating a 6‐connected triptycene‐based linker with a 4‐connected porphyrin‐based linker. Characterized with a highly interconnected mesoporous scaffold and good stability, TUS‐64 shows efficient drug loading and controlled release for five different drugs in simulated body fluid environment, demonstrating the competency of TUS‐64 as drug nanocarriers.

Three-dimensional covalent organic frameworks with pto and mhq-z topologies based on Tri- and tetratopic linkers

“…3e), larger than that of other reported 3D COFs (see Supplementary Tab. 1) [38][39][40][41] . Note that pto is an open porous edgetransitive and highly symmetric 3D structure, which shows the same apertural shapes when viewed from three orthogonal vectors (Fig.…”

Covalent organic frameworks in heterogeneous catalysis: recent advances and future perspective

“…11 COFs set them apart from other established porous materials, such as carbons, zeolites, mesoporous silica, MOFs, and amorphous porous polymers, due to their hallmark features, including high crystallinity, ultralow density ( e.g. , 0.106 g cm −3 for TUS-64), 12 large surface areas ( e.g. , 5083 m 2 g −1 for DBA-3D-COF-1), 13 adjustable pore aperture ( e.g.…”

“…In 2005, Yaghi and co-workers overcame this impasse and successfully synthesized the first two COFs (COF-1 and COF-5) through the self-condensation of boronic acids or the cocondensation of boronic acids with catechols. 11 COFs set them apart from other established porous materials, such as carbons, zeolites, mesoporous silica, MOFs, and amorphous porous polymers, due to their hallmark features, including high crystallinity, ultralow density (e.g., 0.106 g cm À3 for TUS-64), 12 large surface areas (e.g., 5083 m 2 g À1 for DBA-3D-COF-1), 13 adjustable pore aperture (e.g., 10.0 nm for TDCOF-3), 14 excellent thermal stability (e.g., 600 1C for COF-5), 11 high carrier mobility (e.g., 35.4 cm 2 V À1 s À1 for NiPc-NH-CoPcF 8 COF), 15 bespoke structural backbones, and versatile synthesis methods. These unique features make COFs highly promising for diverse niche applications, particularly in heterogeneous catalysis.…”

Record Ultralarge‐Pores, Low Density Three‐Dimensional Covalent Organic Framework for Controlled Drug Delivery**

“…Herein, we report a new 3D non‐interpenetrated stp topology COF, namely TUS‐64, with the largest pore size among 3D COFs (47 Å) and ultra‐low density (0.106 g cm −3 ) by linking a D 3h ‐symmetric triangular prism node, 2,3,6,7,14,15‐hexakis(4′‐formylphenyl)triptycene (HFPTP), with a C 4 ‐symmetric square planar linker, 5,10,15,20‐tetrakis(4‐aminophenyl)porphyrin (TAPP) (Scheme 1). Of note, subsequent to the online availability of this manuscript in open access preprint archive, [32] a 3D COF with 2‐fold interpenetrated stp topology, ZJUT‐1, constructed from same building units has been published [33] . However, ZJUT‐1 crystallizes in the space group of P 1 and exhibits 2‐fold interpenetrated stp topology, whereas TUS‐64 crystallizes in the space group of P 6/ m and exhibits non‐ interpenetrated stp topology.…”