Recovery from end-stage ischemic cardiomyopathy during long-term LVAD support

Pietsch, Lars; Laube, Horst; Baumann, G.; Konertz, Wolfgang

doi:10.1016/s0003-4975(98)00507-4

Cited by 18 publications

(18 citation statements)

References 5 publications

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“…Five days after ex vivo delivery of 2ϫ10 11 total viral particles (TVP) of Adv-␤Gal, the transgene was robustly expressed in the transplanted heart, as confirmed by histological galactosidase staining ( Figure 3A). Expression of Adv-␤ 2 AR was dose-dependent, and both 1ϫ10 11 (1ϫ) and 2ϫ10 11 (2ϫ) TVP significantly increased ␤AR density, with the 2ϫ dose increasing it to 511.6Ϯ101.5 fmol/mg membrane protein (nϭ4).…”

Section: Transgene Expressionmentioning

confidence: 81%

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Myocardial Gene Transfer and Overexpression of β ₂ -Adrenergic Receptors Potentiates the Functional Recovery of Unloaded Failing Hearts

et al. 2002

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Background-Mechanical assistance of the failing left ventricle (LV) can lead to functional recovery after a period of unloading, including restoration of ␤-adrenergic receptor (␤AR) inotropic reserve. We tested whether prolonged LV unloading of failing rabbit hearts by use of a heterotopic transplantation technique could lead to recovery and whether adenoviral gene transfer of a ␤ 2 AR transgene (Adv-␤ 2 AR) could alter this process. Methods and Results-Heart failure was induced by coronary artery ligation in adult New Zealand White rabbits. After 4 weeks, failing hearts were heterotopically transplanted into recipient rabbits, allowing normal coronary perfusion but complete LV unloading. We also placed an LV latex balloon for remote access and in vivo physiological analysis. We found that there was reversal of signaling and functional abnormalities after 30 days of unloading. In another set of failing hearts, we randomly delivered, at the time of transplantation, either 2ϫ10 11 viral particles of Adv-␤ 2 AR or saline via the coronary arteries. Sham-operated animals with nonfailing hearts served as controls. After 5 days of unloading, in vivo LV contractility (LV dP/dt max ) and relaxation (LV dP/dt min ) were significantly decreased in saline-treated failing hearts compared with control nonfailing hearts (PϽ0.05). In failing hearts treated with Adv-␤ 2 AR, however, LV dP/dt max and LV dP/dt min were improved in response to higher preloads (PϽ0.05) and ␤AR stimulation (PϽ0.01). Conclusions-Heterotopic transplantation in the rabbit does allow recovery of the failing heart, and ␤ 2 AR overexpression acutely enhances this functional improvement. Accordingly, genetic manipulation of ␤AR signaling may represent a novel molecular adjunct to mechanical assistance to facilitate functional myocardial recovery.

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Section: Transgene Expressionmentioning

confidence: 81%

“…Expression of Adv-␤ 2 AR was dose-dependent, and both 1ϫ10 11 (1ϫ) and 2ϫ10 11 (2ϫ) TVP significantly increased ␤AR density, with the 2ϫ dose increasing it to 511.6Ϯ101.5 fmol/mg membrane protein (nϭ4). This represents Ͼ8 times the value measured in control hearts ( Figure 3B; PϽ0.005).…”

Section: Transgene Expressionmentioning

confidence: 99%

Myocardial Gene Transfer and Overexpression of β ₂ -Adrenergic Receptors Potentiates the Functional Recovery of Unloaded Failing Hearts

et al. 2002

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“…All the studies assessed firstgeneration devices with one case report of the Abiomed LVAD, 104 one case report of the HeartMate LVAD, 105 one case report of the Novacor LVAD 106 , two case reports of the Thoratec LVAD, 107,108 and two case series evaluations of the Toyobo LVAD. 109,110 There were no studies of second-generation devices included in the systematic review.…”

Section: Quantity Of Researchmentioning

confidence: 99%

“…A case study reported survival of one patient supported with a Novacor LVAD until recovery of heart function ( Table 24 and Appendix 20). 106 The 54-year-old man with cardiac failure refractory to medical therapies and contraindicated to heart transplant was well enough to be transferred to a partial outpatient status 6 weeks after implant and 3 months later was successfully weaned from the device. The patient was discharged home after 6 weeks and was alive and well at 6 months follow-up.…”

Section: First-generation Lvadsmentioning

confidence: 99%

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Cost–effectiveness of left ventricular-assist devices in end-stage heart failure

Hutchinson¹,

Scott²,

Clegg³

et al. 2008

Expert Review of Cardiovascular Therapy

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Biological and Functional Effects of Chronic Mechanical Support Induced by Left Ventricular Assist Devices on Failing Human Myocardium

Torre‐Amione

Wallace

Frazier

Developments in Cardiovascular Medicine

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Recovery from end-stage ischemic cardiomyopathy during long-term LVAD support

Cited by 18 publications

References 5 publications

Myocardial Gene Transfer and Overexpression of β ₂ -Adrenergic Receptors Potentiates the Functional Recovery of Unloaded Failing Hearts

Myocardial Gene Transfer and Overexpression of β ₂ -Adrenergic Receptors Potentiates the Functional Recovery of Unloaded Failing Hearts

Cost–effectiveness of left ventricular-assist devices in end-stage heart failure

Biological and Functional Effects of Chronic Mechanical Support Induced by Left Ventricular Assist Devices on Failing Human Myocardium

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Recovery from end-stage ischemic cardiomyopathy during long-term LVAD support

Cited by 18 publications

References 5 publications

Myocardial Gene Transfer and Overexpression of β 2 -Adrenergic Receptors Potentiates the Functional Recovery of Unloaded Failing Hearts

Myocardial Gene Transfer and Overexpression of β 2 -Adrenergic Receptors Potentiates the Functional Recovery of Unloaded Failing Hearts

Cost–effectiveness of left ventricular-assist devices in end-stage heart failure

Biological and Functional Effects of Chronic Mechanical Support Induced by Left Ventricular Assist Devices on Failing Human Myocardium

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Product

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Myocardial Gene Transfer and Overexpression of β ₂ -Adrenergic Receptors Potentiates the Functional Recovery of Unloaded Failing Hearts

Myocardial Gene Transfer and Overexpression of β ₂ -Adrenergic Receptors Potentiates the Functional Recovery of Unloaded Failing Hearts