Recovery from large medial thalamic lesions as a result of electroconvulsive therapy.

Vanderwolf, C.H.

doi:10.1136/jnnp.31.1.67

Cited by 10 publications

(5 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Medialthalamus-damaged rats were tested on a one-way avoidance task, given electroconvulsive shock, septal lesions, or a control treatment, then retested on the one-way task. Both electroconvulsive shock and septal damage produced an improvement in performance in about half the rats tested, while control rats remained unchanged (Vanderwolf, 1964(Vanderwolf, , 1968. These findings support the hypothesis that septal damage and electroconvulsive shock disrupt mechanisms which normally control activity in a movement trigger system.…”

Section: Behavioral Effects Of Medialsupporting

confidence: 68%

“…The lesions were relatively extensive, involving the medial and midline nuclei as well as the intralaminar nuclei and habenula. Details of most of the work are provided in earlier publications (Vanderwolf, 1962(Vanderwolf, , 1963a(Vanderwolf, , 1964(Vanderwolf, , 1966(Vanderwolf, , 1967b(Vanderwolf, , 1968(Vanderwolf, , 1969b.…”

Section: Behavioral Effects Of Medialmentioning

confidence: 99%

See 1 more Smart Citation

Limbic-diencephalic mechanisms of voluntary movement.

1971

Psychological Review

483

149

View full text Add to dashboard Cite

Data from a series of brain-behavior experiments utilizing techniques of ablation, ICS, and electrical recording emphasize the importance of the concept of levels of function in understanding behavior. Initiation, performance, and cessation of voluntary behaviors (e.g., walking, manipulating objects) are associated with activation of ascending pathways from the diencephalon to the hippocampus and neocortex. More automatic behaviors (e.g., chewing, emotional expression) are not directly dependent on these pathways, even when they occur as CRs. Electrical recordings indicate that hippocampal activity, in particular, is closely related to behavior. Wave morphology, amplitude, and frequency, are all related to different aspects of concurrent motor activity. Problems of the definition and mechanism of "voluntary" and "automatic" control of movement are discussed. (7 p. ref.)

show abstract

Section: Behavioral Effects Of Medialsupporting

confidence: 68%

Section: Behavioral Effects Of Medialmentioning

confidence: 99%

Limbic-diencephalic mechanisms of voluntary movement.

1971

Psychological Review

483

149

View full text Add to dashboard Cite

show abstract

“…Ample experimental studies have focused on the understanding of oscillations in the hippocampus and corresponding behavior. For example, in the rat hippocampus, θ state occurs during walking, running, rearing, and exploratory sniffing, as well as during REM sleep [ 73 , 80 , 81 , 82 ]. Hippocampal θ is associated with stimuli in the working memory instead of the reference memory condition [ 73 ], thus it could be a tag for short-term memory [ 83 ].…”

Section: Eeg In Normal Conditionsmentioning

confidence: 99%

“…Hippocampal θ is associated with stimuli in the working memory instead of the reference memory condition [ 73 ], thus it could be a tag for short-term memory [ 83 ]. Additional evidence also suggests that the hippocampal θ is associated with spontaneous movements in monkeys (7–9 Hz) [ 84 ] and locomotion in rodents [ 82 ]. Compared to hippocampal θ, the role of cortical θ is less clear.…”

Section: Eeg In Normal Conditionsmentioning

confidence: 99%

Perturbation of Brain Oscillations after Ischemic Stroke: A Potential Biomarker for Post-Stroke Function and Therapy

Rabiller

Nishijima

et al. 2015

IJMS

100

View full text Add to dashboard Cite

Brain waves resonate from the generators of electrical current and propagate across brain regions with oscillation frequencies ranging from 0.05 to 500 Hz. The commonly observed oscillatory waves recorded by an electroencephalogram (EEG) in normal adult humans can be grouped into five main categories according to the frequency and amplitude, namely δ (1–4 Hz, 20–200 μV), θ (4–8 Hz, 10 μV), α (8–12 Hz, 20–200 μV), β (12–30 Hz, 5–10 μV), and γ (30–80 Hz, low amplitude). Emerging evidence from experimental and human studies suggests that groups of function and behavior seem to be specifically associated with the presence of each oscillation band, although the complex relationship between oscillation frequency and function, as well as the interaction between brain oscillations, are far from clear. Changes of brain oscillation patterns have long been implicated in the diseases of the central nervous system including ischemic stroke, in which the reduction of cerebral blood flow as well as the progression of tissue damage have direct spatiotemporal effects on the power of several oscillatory bands and their interactions. This review summarizes the current knowledge in behavior and function associated with each brain oscillation, and also in the specific changes in brain electrical activities that correspond to the molecular events and functional alterations observed after experimental and human stroke. We provide the basis of the generations of brain oscillations and potential cellular and molecular mechanisms underlying stroke-induced perturbation. We will also discuss the implications of using brain oscillation patterns as biomarkers for the prediction of stroke outcome and therapeutic efficacy.

show abstract

“…Several treatments, including septal lesions (Vanderwolf, 1964), warm-up period (Vanderwolf, 1966), electroconvulsive shock (Vanderwolf, 1968), and chlorpromazine injections (Wuensch & Means, 1976) have been found to partially alleviate the DMT lesion-induced active avoidance deficit. It has been suggested that all of the above treatments improve the performance of DMT-lesioned rats in avoidance conditioning by decreasing the tendency to behaviorally freeze when shocked.…”

mentioning

confidence: 99%

Effect of piracetam on one-way active avoidance in rats with medial thalamic lesions

Abbott

Means

1979

Bull. Psychon. Soc.

View full text Add to dashboard Cite

Rats sustaining either medial thalamic electrolytic lesions or sham operations were injected with either piractam (100 mg/kg), a drug previously shown to enhance acquisition, or saline for 3 consecutive days prior to being tested for shock-flinch threshold and one-way active avoidance. The animals with medial thalamic lesions were found to make fewer avoidances than the sham-operated animals. Piracetam was shown neither to alleviate the lesion-induced avoidance deficit nor to facilitate acquisition in the sham-operated animals. No differences were observed in shock-flinch threshold. 158Rats with relatively large lesions centered in the dorsomedial nucleus of the thalamus (DMT) have been found to be deficient on acquisition of one-way active avoidance (Tigner, 1972;Vanderwolf, 1964Vanderwolf, , 1966Vanderwolf, , 1967 Wuensch & Means, 1976). Several treatments, including septal lesions (Vanderwolf, 1964), warm-up period (Vanderwolf, 1966), electroconvulsive shock (Vanderwolf, 1968), and chlorpromazine injections (Wuensch & Means, 1976) have been found to partially alleviate the DMT lesion-induced active avoidance deficit. It has been suggested that all of the above treatments improve the performance of DMT-lesioned rats in avoidance conditioning by decreasing the tendency to behaviorally freeze when shocked. Further, it has been shown that amphetamine injections decrease the freezing behavior of DMT-lesioned rats in a two-choice discrimination task, but they do not improve choice performance (Wuensch, Broom, Means, & Harris, 1978). Thus, several treatments have been found to decrease the freezing behavior of DMT-Iesioned rats, but no treatment has been found that directly affects the acquisition process.Piracetam (2-pyrrolidone acetamide) has been proposed as a learning-facilitation drug (Giurgea, Note 1). In humans, it has been shown to alleviate some of the symptoms of senility (Stegnik, 1972). In rats, piracetam has been found to facilitate acquisition of a lightsignaled active avoidance in a Y maze (Wolthuis, 1971) and to reduce errors and escape latency in a four-choice water-filled maze (Giurgea & Mouravieff-Lesiusse, 1972). It has also been shown to protect against the amnestic effects of electroconvulsive shock (Sara & David-Remacle, 1974) and hypoxia (Giurgea, Lefevre, & Lescrenier, 1971;Sara & Lefevre, 1972 METHOD SubjectsA total of 41 individually housed , male, Long-Evans rats from the East Carolina University colony were used. All rats were given food and water ad lib.The study involved four groups. Eight rats received lesions centered on the DMT and were treated with piracetam (Group D-P). Group SoP (n =12) received sham operations and treatment with piracetam . Group D-S (n =9) received lesions centered on the DMT and saline. Group S-S (n =12) received sham operations and saline. ProcedureSurgery. Surgery was done under clean conditions ; sodium pentobarbital was used as anesthesia (Nembutal, 50 mg/kg) and .2 cc of BicilIin was administered to prevent infection. Subjects in Group D-P and Group D-...

show abstract

Recovery from large medial thalamic lesions as a result of electroconvulsive therapy.

Cited by 10 publications

References 18 publications

Limbic-diencephalic mechanisms of voluntary movement.

Limbic-diencephalic mechanisms of voluntary movement.

Perturbation of Brain Oscillations after Ischemic Stroke: A Potential Biomarker for Post-Stroke Function and Therapy

Effect of piracetam on one-way active avoidance in rats with medial thalamic lesions

Contact Info

Product

Resources

About