Recovery from pre‐operative sedation with clonidine—brain stem auditory evoked response

Kumar, Ashok; Op, Tandon; Bhattacharya, Abhijit; Bose, S.; Kundra, Pankaj

doi:10.1111/j.1365-2044.1994.tb03529.x

Cited by 8 publications

(3 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to their ability to reduce IOP and dampen the sympathetic response, alpha 2 agonists find useful application in ophthalmic procedures. Clonidine [4][5][6] and dexmedetomidine also have these characteristics as alpha 2 agonists. Dexmedetomidine is extremely selective and specific for the alpha-2 adrenergic receptor, whereas clonidine acts on both the alpha-1 and alpha-2 adrenergic receptors.…”

Section: To Study Dexmedetomidine's Effect On Intraocular Pressure Af...mentioning

confidence: 99%

To study dexmedetomidine’s effect on intraocular pressure after succinylcholine and endotracheal intubation

Surya Gowthami Katika,

Sri Harsha Merugu,

Jaya Chandra Tentu

et al. 2023

Asian J Med Sci

View full text Add to dashboard Cite

Background: One of the most important preconditions for any anesthetic operation is perioperative hemodynamic stability during laryngoscopy and intubation, which has been the subject of extensive research and documentation. Numerous approaches have been proposed to protect the patient from the sympathetic reaction, intraocular pressure (IOP) response, and catecholamine response during laryngoscopy and intubation. Aims and Objectives: To study the efficacy of two doses of intravenous dexmedetomidine premedication given as a single bolus dose over 10 min, 0.4 μg/kg and 0.6 μg/kg, 10 min before induction in preventing the rise of intraocular pressure following succinylcholine administration and endotracheal intubation. Materials and Methods: A retrospective randomized study was conducted. Ethical committee permission and signed informed consent were obtained from 60 eligible patients before the trial began. Results: Premedication with either 0.4 mcg/kg I.V. or 0.6 mcg/kg I.V. of dexmedetomidine diluted in normal saline at a 2 mcg/mL concentration administered over 10 min before induction resulted in significant obtundation of the rise in IOP associated with succinylcholine administration and intubation. Sympathetic response to laryngoscopy and intubation was also significantly diminished. The dose of 0.4 mcg/kg I.V. produced the best hemodynamic stability. Conclusion: Therefore, from the above research it can be concluded that, before succinylcholine delivery and intubation, dexmedetomidine 0.4 mcg/kg I.V. can be used as a premedication in situations where an increase in IOP could be hazardous.

show abstract

Section: To Study Dexmedetomidine's Effect On Intraocular Pressure Af...mentioning

confidence: 99%

To study dexmedetomidine’s effect on intraocular pressure after succinylcholine and endotracheal intubation

Surya Gowthami Katika,

Sri Harsha Merugu,

Jaya Chandra Tentu

et al. 2023

Asian J Med Sci

View full text Add to dashboard Cite

show abstract

“…In a recent study, Kumar et al [22] observed that preoperative sedation with oral clonidine (5 mg.kg À1 ) causes no significant increase in the interpeak latencies and APL of BAEP waves I-V on recovery from cataract extraction under regional block. In this study, in the diazepam (oral) group there was a significant increase in interpeak latencies and APL of waves I-V. A few other authors have also demonstrated significant changes in evoked potentials following the administration of diazepam [91,92].…”

Section: Influence Of Anaesthetic Drugs On Sepsmentioning

confidence: 99%

“…Brainstem auditory-evoked potentials (BAEP, Fig. 2) are recorded during procedures in the posterior cranial fossa [16][17][18][19][20][21], to assess recovery from pre-operative sedation in regional anaesthesia [22] and during chronic pain management [23]. Visual-evoked potentials (VEP, Fig.…”

Section: Evoked Potentialsmentioning

confidence: 99%

Evoked potential monitoring in anaesthesia and analgesia

2000

Self Cite

View full text Add to dashboard Cite

SummaryElectrophysiological monitoring of selected neural pathways of the brain, brainstem, spinal cord and peripheral nervous system has become mandatory in some surgery of the nervous system where preventable neural injury can occur. Evoked potentials are relatively simple methods of testing the integrity of various aspects of the nervous system. This review covers the variety of evoked potentials that can be monitored and outlines the principles of their measurement. Their use in specific situations and how factors such as anaesthesia might affect them is presented.

show abstract