Recovery from rabies, a universally fatal disease

Manoj, Sharmila; Mukherjee, Arindam; Johri, Sharad; Kumar, K.V.S. Hari

doi:10.1186/s40779-016-0089-y

Cited by 16 publications

(10 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our model indicates that humans and animals are closely connected by zoonoses and the food supply chain [ 34 , 35 ]. Some common zoonoses include avian influenza [ 36 , 37 ], leishmaniasis [ 38 ], Middle East respiratory syndrome coronavirus prevention [ 39 ], rabies [ 40 , 41 ] etc. Additionally, the rising demand for animal protein for human consumption, resulting in a shift towards larger, more complex animal production operations, has spurred the increased use of antimicrobials.…”

Section: Discussionmentioning

confidence: 99%

A system dynamics approach to understanding the One Health concept

et al. 2017

View full text Add to dashboard Cite

There have been many terms used to describe the One Health concept, including movement, strategy, framework, agenda, approach, among others. However, the inter-relationships of the disciplines engaged in the One Health concept have not been well described. To identify and better elucidate the internal feedback mechanisms of One Health, we employed a system dynamics approach. First, a systematic literature review was conducted via searches in PubMed, Web of Knowledge, and ProQuest with the search terms: ‘One Health’ and (concept* or approach*). In addition, we used the HistCite® tool to add significant articles on One Health to the library. Then, of the 2368 articles identified, 19 were selected for evaluating the inter-relationships of disciplines engaged in One Health. Herein, we report a visually rich, theoretical model regarding interactions of various disciplines and complex problem descriptors engaged in One Health problem solving. This report provides a conceptual framework for future descriptions of the interdisciplinary engagements involved in One Health.

show abstract

Section: Discussionmentioning

confidence: 99%

A system dynamics approach to understanding the One Health concept

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Asklepios is but one example of such a renaissance by a consortium of scientists whose focal research aims include the following: the identification of drugs that would inhibit RABV replication, the testing of molecules that may minimize detrimental host responses during RABV infection, the determination of whether alteration of the blood-brain barrier (BBB) permeability could improve treatment effectiveness, and validation of the potential success for such an approach in vivo ( http://asklepiosfp7.eu/ ). Regardless of technical insights, required expertise, the associated expense and related ethics of effort issues, there is also the prospect of survivorship with sequelae and the need for lengthy, potentially lifelong, rehabilitation and quality-of-life considerations 63 . To make progress, whether in veterinary or human medicine, a more complete approach to rabies treatment should be taken, combining insights on rabies pathobiology gleaned from both experimental animal research and individual human case studies 64 .…”

Section: Controversy On the Horizon: A Paradigm Shift To Treating Thementioning

confidence: 99%

Lyssaviruses and rabies: current conundrums, concerns, contradictions and controversies

2017

View full text Add to dashboard Cite

Lyssaviruses are bullet-shaped, single-stranded, negative-sense RNA viruses and the causative agents of the ancient zoonosis rabies. Africa is the likely home to the ancestors of taxa residing within the Genus Lyssavirus, Family Rhabdoviridae. Diverse lyssaviruses are envisioned as co-evolving with bats, as the ultimate reservoirs, over seemingly millions of years. In terms of relative distribution, overt abundance, and resulting progeny, rabies virus is the most successful lyssavirus species today, but for unknown reasons. All mammals are believed to be susceptible to rabies virus infection. Besides reservoirs among the Chiroptera, meso-carnivores also serve as major historical hosts and are represented among the canids, raccoons, skunks, mongooses, and ferret badgers. Perpetuating as a disease of nature with the mammalian central nervous system as niche, host breadth alone precludes any candidacy for true eradication. Despite having the highest case fatality of any infectious disease and a burden in excess of or comparative to other major zoonoses, rabies remains neglected. Once illness appears, no treatment is proven to prevent death. Paradoxically, vaccines were developed more than a century ago, but the clear majority of human cases are unvaccinated. Tens of millions of people are exposed to suspect rabid animals and tens of thousands succumb annually, primarily children in developing countries, where canine rabies is enzootic. Rather than culling animal populations, one of the most cost-effective strategies to curbing human fatalities is the mass vaccination of dogs. Building on considerable progress to date, several complementary actions are needed in the near future, including a more harmonized approach to viral taxonomy, enhanced de-centralized laboratory-based surveillance, focal pathogen discovery and characterization, applied pathobiological research for therapeutics, improved estimates of canine populations at risk, actual production of required vaccines and related biologics, strategies to maximize prevention but minimize unnecessary human prophylaxis, and a long-term, realistic plan for sustained global program support to achieve success in disease control, prevention, and elimination.

show abstract

“…Many patients still undergo a rehabilitation process at home or in specialized centers. There are reports of patients who remain bedridden and require home care due to disease sequelae 35,[37][38][39] .…”

Section: Discussionmentioning

confidence: 99%

Comparing clinical protocols for the treatment of human rabies: the Milwaukee protocol and the Brazilian protocol (Recife)

Ledesma

Lemos

Horta

2020

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Introduction: Rabies is a major and seriously neglected public health problem worldwide. A treatment consisting of supportive therapy with the use of drugs that show antiviral activity is called the Milwaukee Protocol. In Brazil, this protocol was adapted to the national reality and called the Recife Protocol. In this study, we compared the Milwaukee Protocol with the Recife Protocol, assessing the differences and how these differences may change the course of clinical management. Methods: We searched electronic databases for the use of anti-rabies treatments. A total of 65 articles were published between 2004 and 2019. Results: The protocols have similarities in care related to rabies patients and are important for the treatment of patients in intensive care units. Both protocols indicate deep sedation, antiviral use, constant concern with electrolyte balance, and vasoconstriction related to the condition. Many differences were observed in this study. For the Milwaukee Protocol, sedation should be gradually removed after the eighth day, and on the twelfth day, the patient should be without sedation. In the Recife Protocol, in order to avoid immunomodulation, it is recommended to remove sedation according to the titers of neutralizing antibodies to the rabies virus in the cerebral spinal fluid. Conclusions: In addition to the differences and similarities raised, our findings indicate that these protocols require a large center for rabies treatment, but the disease most often occurs in places where resources and hospital infrastructure are scarce.

show abstract

Recovery from rabies, a universally fatal disease

Cited by 16 publications

References 8 publications

A system dynamics approach to understanding the One Health concept

A system dynamics approach to understanding the One Health concept

Lyssaviruses and rabies: current conundrums, concerns, contradictions and controversies

Comparing clinical protocols for the treatment of human rabies: the Milwaukee protocol and the Brazilian protocol (Recife)

Contact Info

Product

Resources

About