Recovery From Sevoflurane Anesthesia in Horses: Comparison to Isoflurane and Effect of Postmedication With Xylazine

Matthews, Nora S.; Hartsfield, Sandee M.; Mercer, D.; Beleau, M. H.; Mackenthun, A

doi:10.1111/j.1532-950x.1998.tb00160.x

Cited by 98 publications

(105 citation statements)

References 8 publications

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“…The results of the study showed no statistically significant differences in cardiovascular or respiratory effects when comparing sevoflurane to isoflurane, which are consistent with previous reports in dogs, sheep, goats, humans and horses (Aida et al, 1996;Ebert et al, 1995;Hikasa et al, 1998;Matthews et al, 1998;Mutoh et al, 1997). Attempts to stand and recovery times appeared to occur faster for sevoflurane upon review of the data, although not statistically significant.…”

Section: Resultssupporting

confidence: 82%

“…Recovery quality of sevoflurane has been reported as comparable to or better than isoflurane in dogs and horses (Johnson et al, 1998;Matthews et al, 1998). Although this study found no statistical difference in the time to first movement, time to extubation, time to standing or attempts to stand between the two anesthetics, sevoflurane anesthetized calves appeared to awaken from anesthesia faster as indicated by the less time to first movement and extubation.…”

Section: Discussioncontrasting

confidence: 52%

“…In previous studies, the duration of recovery to standing has always been shorter with sevoflurane than with isoflurane in horses, sheep and dogs (Hikasa et al, 2000;Johnson et al, 1998;Matthews et al, 1998). Recovery quality of sevoflurane has been reported as comparable to or better than isoflurane in dogs and horses (Johnson et al, 1998;Matthews et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Isoflurane and Sevoflurane Anesthesia in Holstein Calves for Placement of Portal and Jugular Vein Cannulas

Sellers

Lin

Chamorro

et al. 2013

American Journal of Animal and Veterinary Sciences

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Isoflurane and sevoflurane are the two most commonly used inhalation anesthetics in veterinary medicine today. This study compared the anesthetic effects between isoflurane and sevoflurane in 17 calves undergoing surgery for placement of portal and jugular vein cannulas. Using a randomized control trial, calves were assigned to receive sevoflurane or isoflurane. Anesthesia was induced with xylazine and ketamine then maintained with the assigned inhalation anesthetic. Parameters for heart rate, respiratory rate, indirect blood pressures, oxygen hemoglobin saturation and end-tidal carbon dioxide were monitored and recorded during surgery. The anesthetic concentrations of the vaporizers were adjusted according to the calves' responses, e.g., blood pressure, eye position, respiratory and heart rate, to surgical stimulation. Upon discontinuation of the inhalation anesthetic, calves were placed in sternal recumbency and recovery variables including time to extubation, time to first movement, attempts to stand and time to standing were observed and recorded. Statistical analysis was performed using a two-sample t-test on the recorded variables. There were no statistical differences between isoflurane and sevoflurane for any of the parameters recorded during anesthetic maintenance or recovery. The results of this study showed a faster time to first movement and extubation, 3.38±1.85 min and 11.75±3.73 min for sevoflurane compared to 7.56±5.34 min and 15.56±8.69 min for isoflurane, respectively. Attempts to stand were 3.00±2.14 for sevoflurane and 3.22±1.79 for isoflurane. Though the time to standing during recovery was not statistically different between anesthetics, the values did indicate a quicker trend of recovery from sevoflurane. Both inhalation anesthetics produced comparable anesthetic qualities and there were no statistical differences between the parameters recorded during maintenance of anesthesia. On the basis of the reported results, sevoflurane and isoflurane are suitable inhalation anesthetics for use in calves. However, present cost of sevoflurane is a limiting factor for its use in food animals.

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Section: Resultssupporting

confidence: 82%

Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

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Comparison of Isoflurane and Sevoflurane Anesthesia in Holstein Calves for Placement of Portal and Jugular Vein Cannulas

Sellers

Lin

Chamorro

et al. 2013

American Journal of Animal and Veterinary Sciences

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“…However, adverse effects or toxicosis may appear if higher doses of fentanyl are administered. In any case, if the horses in Group SF were assisted and appropriate agents were administered, the qualities of the recoveries would be improved and become similar to those previously described for horses recovering from sevoflurane anesthesia [9,13].…”

Section: Discussionmentioning

confidence: 84%

Effects of Intravenous Fentanyl Administration on End-Tidal Sevoflurane Concentrations in Thoroughbred Racehorses undergoing Orthopedic Surgery

Ohta

Wakuno

Okada

et al. 2010

The Journal of Veterinary Medical Science

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ABSTRACT. To evaluate the effects of IV fentanyl administration on the end-tidal sevoflurane concentration (ET SEVO ) in thoroughbred racehorses, the ET SEVO required for internal fixation of longitudinal fractures was compared between horses anesthetized with sevofluranefentanyl (Group SF; n=9) and those anesthetized with sevoflurane alone (Group S; n=9). The loading dose of fentanyl (5.0 g/kg) was administered over 15 min followed by a maintenance dose of fentanyl (0.1 g/kg/min) throughout the operation in Group SF. The mean ET SEVO during the operation in Group SF (2.6  0.2%) was significantly lower than in Group S (3.0  0.3%). The plasma fentanyl concentrations (6.12  0.88 to 7.78  1.12 ng/ml) in 7 out of 9 horses in Group SF were stable and did not change significantly throughout the operation. The mean dobutamine infusion rate required for maintaining a mean arterial blood pressure between 60 and 80 mmHg during the operation in Group SF (0.56  0.30 g/kg/min) was significantly lower than in Group S (0.90  0.16 g/kg/min). The qualities of the recoveries were clinically acceptable, and serious complications were not observed in either group. In conclusion, continuous IV fentanyl administration reduced the sevoflurane requirement by 13% in thoroughbred racehorses undergoing orthopedic surgery; however, fentanyl was considered to be less effective in horses compared with other species.

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“…In several studies agitation has been reported in people after anesthesia (29,30); however, Matthews et al (31) reported no complications in various animal species such as horse. Likewise, we did not find such complications in Angora goats.…”

Section: Discussionmentioning

confidence: 99%

Comparison of sevoflurane and isoflurane effects on cardiovascular andrespiratory system during spontaneous ventilation in Angora goats

Kumandaş¹,

Elma²

2015

Turk J Vet Anim Sci

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IntroductionIsoflurane and sevoflurane are noncombustible halogenated anesthetic agents. In addition to a faster anesthesia induction and shorter recovery time, isoflurane also provides good muscle relaxation. Sevoflurane is more preferable than isoflurane because it has lower irritation of the respiratory tract than isoflurane and it has some advantages such as easy induction and a fast recovery compared to isoflurane (1-3).Propofol, a nonbarbiturate derivative, is a sedative and hypnotic drug that can be used in small animals for anesthesia and maintenance of sedation. Due to its shorter half-life and absence of accumulation in the body (4-6), it can be used safely in animals such as small ruminants (4,7). Information of the possible side effects of these types of anesthetics on small ruminants, however, is not present yet (8)(9)(10)(11)(12).Goats are preferred as an animal model in experimental studies such as orthopedic, cardiovascular, respiratory, and cerebrovascular studies (13-15). Sevoflurane, isoflurane, and halothane are often used as anesthetic agents. However, anesthetic requirements have not been determined in the goat for these agents accurately. Therefore, the aim of this research was to compare the anesthetic effects of two different inhalation anesthetics that are used in the maintenance of anesthesia with propofol medication. Materials and methodsThe study was approved by the Animal Research Local Ethics Committee of Kırıkkale University (Decision No: 70/09). Seven healthy adult female Angora goats were used in this study. Prestudy screening included a physical examination and complete blood count to ensure animals were in good health. The same goats were used for both anesthesia groups within a 2-week interval. Once anesthesia was induced with propofol, it was maintained either with isoflurane or sevoflurane.Feed and water were withheld from animals 18 h and 2 h prior to anesthesia respectively in order to prevent ruminal tympani during anesthesia. The medial auricular artery was catheterized (Wellcath-x plus 22G, Vellmed, Turkey) to measured systolic arterial pressure (SAP), diastolic arterial pressure (DAP), and mean arterial pressure (MAP). The caudal auricular vein was Abstract: Seven healthy Angora goats were used to compare the effects of isoflurane and sevoflurane on the cardiovascular and respiratory systems during anesthesia periods. Once anesthesia was induced with propofol at 5.1 ± 0.9 mg/kg, it was maintained with isoflurane at 1%-3% in the first treatment period and sevoflurane at 2%-4% in the second treatment period after a 15-day interval. Heart rates measured immediately after anesthesia induction and 5 min later were found to be statistically significant between anesthetic groups (P < 0.05). Mean blood pressure in the isoflurane group decreased (75.7 ± 7.2 to 59.8 ± 9.8 mmHg) (P < 0.05) throughout the anesthesia period. It was determined that respiratory rate in sevoflurane treatment was lower than that in isoflurane treatment. In terms of time to stand up, sevoflurane-adminis...

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Recovery From Sevoflurane Anesthesia in Horses: Comparison to Isoflurane and Effect of Postmedication With Xylazine

Abstract: Sevoflurane anesthesia in horses may contribute to a shorter, safer recovery from anesthesia.

Cited by 98 publications

References 8 publications

Comparison of Isoflurane and Sevoflurane Anesthesia in Holstein Calves for Placement of Portal and Jugular Vein Cannulas

Comparison of Isoflurane and Sevoflurane Anesthesia in Holstein Calves for Placement of Portal and Jugular Vein Cannulas

Effects of Intravenous Fentanyl Administration on End-Tidal Sevoflurane Concentrations in Thoroughbred Racehorses undergoing Orthopedic Surgery

Comparison of sevoflurane and isoflurane effects on cardiovascular andrespiratory system during spontaneous ventilation in Angora goats

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