Recovery of 18F from [18O] water by electrochemical method

Saito, Fuminori; Nagashima, Yasuyuki; Kurihara, Toshikazu; Suzuki, N.; Kim, Jaehong; Wei, Long; Itoh, Yoshiko; Gotō, Akira; Hyodo, Toshio

doi:10.1016/s0969-8043(01)00133-6

Cited by 6 publications

(1 citation statement)

References 10 publications

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“…Saito and coworkers tested [ 18 F]fluoride electrodeposition on carbon and platinum rods. Electrodeposition efficiency was found to be up to 97 % when carbon rods were used whereas only 9 % was achieved for platinum rods [26f] . Reischl and coworkers also tested platinum as an alternative anode but no adsorption of [ 18 F]fluoride was observed [27] .…”

Section: Electrochemical (Radio)fluorinationmentioning

confidence: 99%

Electrochemical Radiofluorination of Small Molecules: New Advances

Hernández-Valdés

Sadeghi

2021

The Chemical Record

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The development of new 18F‐based radiopharmaceuticals constantly demands innovations in the search for new radiofluorination methods. [18F]fluoride is the simplest and most convenient chemical form of the isotope for the synthesis of 18F‐based radiopharmaceuticals. The ease of production and handling, as well as the possibility of obtaining high molar activities, makes it the preferred choice for radiofluorination. However, the use of [18F]fluoride in late‐stage radiofluorination comes with challenges, especially for the radiolabeling of electron‐rich molecules where SN2 and SNAr reactions are not suitable. New developments in fluorination chemistry have been extensively studied to overcome these difficulties. Selective electrochemical oxidation of precursors, using a controlled potential, is one method to create reactive intermediates and overcome the activation energy required for nucleophilic fluorination of electron‐rich moieties. This method has been used for years in cold fluorination of organic molecules and more recently has been adapted as an alternative to traditional radiofluorination methods. Although relatively young, this field stands out as a promising route for the synthesis of new PET probes as well as fluorinated pharmaceuticals. This review focuses on recent advances in electrochemical radiofluorination as an alternative for the late‐stage radiolabeling of organic molecules.

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Section: Electrochemical (Radio)fluorinationmentioning

confidence: 99%