Recovery of Advanced Atrioventricular Block by Cilostazol

Nimura, Asami; Sato, Nobuyuki; Sakuragi, Hitoshi; Koyama, Satoshi; Maruyama, Junichi; Talib, Ahmed Karim; Nakagawa, Naoki; Naka, Sadahiro; Ota, Hisanobu; Tanabe, Yasuko; Takeuchi, Toshiharu; Kawamura, Y.; Hasebe, Naoyuki

doi:10.2169/internalmedicine.50.5228

Cited by 6 publications

(10 citation statements)

References 13 publications

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“…Recent studies have reported the effectiveness of orally administered cilostazol, a phosphodiesterase III inhibitor, in treating bradyarrhythmia in humans and animals [ 9 , 11 , 12 , 14 , 17 ]. Cilostazol is a platelet-aggregation inhibitor and has been administered intrinsically for preventing relapse in patients with cerebral infarction or chronic arterial occlusion.…”

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confidence: 99%

Effects of cilostazol on the heart rate in healthy dogs

Fukushima

Kawaguchi

Yamada

et al. 2018

The Journal of Veterinary Medical Science

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Appropriate dosages of cilostazol have not been studied in veterinary patients, and the degrees of heart rate (HR) increase have not been studied in dogs administered cilostazol. Therefore, this study aimed to investigate the degrees of HR increase in healthy dogs administered cilostazol. Thirty healthy beagle dogs (15 males and 15 females; age, 5–8 years) were divided into 3 groups of 10 dogs each and orally administered 2.5, 5, or 10 mg/kg cilostazol (twice a day at 8:00 AM and 8:00 PM for 10 days). Higher HR increases were seen in the 5 mg/kg group than in the 2.5 mg/kg group at all time points except 7:00 AM, 9:00 AM, 1:00 PM, and 4:00 PM (P<0.01). Higher HR increases were also observed in the 10 mg/kg group than in the 2.5 mg/kg group at all time points except 4:00 PM (P<0.01). The 10 mg/kg group showed higher HR increases than the 5 mg/kg group at all time points except 6:00 AM, 7:00 AM, 6:00 PM, and 7:00 PM (P<0.05 for 4:00 PM and 5:00 PM; P<0.01 for the other time points). These results together show that the HR of healthy dogs increased in a dose-dependent manner after cilostazol administration twice a day at doses of 5 to 10 mg/kg. These results provide a useful basis for choosing cilostazol in the treatment of bradyarrhythmia in dogs.

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confidence: 99%

Effects of cilostazol on the heart rate in healthy dogs

Fukushima

Kawaguchi

Yamada

et al. 2018

The Journal of Veterinary Medical Science

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“…11 In addition, recovery of the AV conduction using cilostazol in a human patient with advanced AV block has been reported. 14…”

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confidence: 99%

Long-term management of high-grade atrioventricular block using cilostazol in a cat

Iwasa

Nishii

Takashima

et al. 2019

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 12-year-old neutered female domestic shorthair cat was admitted for syncope. Clinical signs and electrocardiography revealed high-grade atrioventricular (AV) block. Treatment with cilostazol ameliorated the clinical signs and arrhythmia. However, the high-grade AV block recurred on several occasions. After 640 days, the cat presented again with clinical deterioration owing to reoccurrence of the arrhythmia and it died 11 days later. Histopathological examination revealed a loss of conduction cells within the His bundle. Relevance and novel information To our knowledge, this is the first report of high-grade AV block treated with cilostazol in a cat. Treatment with cilostazol prolonged survival for 650 days without pacemaker implantation. Histological findings suggested that the AV block was related to fibrosis of the impulse conduction system.

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“…Cilostazol has positive chronotropic effects and has been used to treat human patients with bradyarrhythmias, such as atrioventricular (AV) block and SSS [2, 9, 10, 12, 15, 19]. Cilostazol has also been reported to have long-term chronotropic effects [5, 9].…”

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confidence: 99%

“…Cilostazol has also been reported to have long-term chronotropic effects [5, 9]. The mechanisms of action of cilostazol include vasodilation resulting in a reflex increase in heart rate (HR), improvement of sinus function by suppression of parasympathetic tone, increased blood flow to the sinus node resulting from coronary artery dilatation, and increased sinus node intracellular cyclic adenosine monophosphate [12]. Cilostazol has been reported to increase the heart rate in experimental dogs [14].…”

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confidence: 99%

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Long term effects of cilostazol in a dog with sick sinus syndrome

Kanno

Suzuki²

2017

The Journal of Veterinary Medical Science

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Sick sinus syndrome (SSS) is a type of bradyarrhythmia that can lead to syncope. Cilostazol has been reported to be an effective treatment for human patients with SSS and other bradyarrhythmias. This report describes the successful long-term treatment with cilostazol in a dog with SSS. A nine-year old intact male Miniature Schnauzer presented with a history of syncopal episodes and unsteady gait. After cilostazol treatment, the total heart rate (HR), mean HR, and frequency of premature ventricular contractions (PVCs) increased, while the maximum HR and maximum pause time decreased. Additionally, the number of syncopal episodes decreased. The dog died suddenly, 1,418 days after the start of cilostazol treatment. Cilostazol may be a useful therapeutic agent in canines with SSS.

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Recovery of Advanced Atrioventricular Block by Cilostazol

Cited by 6 publications

References 13 publications

Effects of cilostazol on the heart rate in healthy dogs

Effects of cilostazol on the heart rate in healthy dogs

Long-term management of high-grade atrioventricular block using cilostazol in a cat

Long term effects of cilostazol in a dog with sick sinus syndrome

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