Recovery of Contour Integration in Relation to LogMAR Visual Acuity during Treatment of Amblyopia in Children

Chandna, Arvind; Gonzalez-Martin, J A; Norcia, Anthony M.

doi:10.1167/iovs.03-0795

Cited by 15 publications

(28 citation statements)

References 33 publications

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“…Contrast sensitivity improves alongside visual acuity (Wali et al, 1991), but contour integration improves faster and more completely than visual acuity (Chandna, Gonzalez-Martin, & Norcia, 2004). On the other hand, abnormalities in visual evoked potentials have been observed even after patching restores visual acuity to normal levels (Weiss & Kelly, 2004).…”

Section: Motion Perception and Amblyopia Treatmentmentioning

confidence: 98%

The effect of occlusion therapy on motion perception deficits in amblyopia

et al. 2015

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There is growing evidence for deficits in motion perception in amblyopia, but these are rarely assessed clinically. In this prospective study we examined the effect of occlusion therapy on motion-defined form perception and multiple-object tracking. Participants included children (3-10years old) with unilateral anisometropic and/or strabismic amblyopia who were currently undergoing occlusion therapy and age-matched control children with normal vision. At the start of the study, deficits in motion-defined form perception were present in at least one eye in 69% of the children with amblyopia. These deficits were still present at the end of the study in 55% of the amblyopia group. For multiple-object tracking, deficits were present initially in 64% and finally in 55% of the children with amblyopia, even after completion of occlusion therapy. Many of these deficits persisted in spite of an improvement in amblyopic eye visual acuity in response to occlusion therapy. The prevalence of motion perception deficits in amblyopia as well as their resistance to occlusion therapy, support the need for new approaches to amblyopia treatment.

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Section: Motion Perception and Amblyopia Treatmentmentioning

confidence: 98%

The effect of occlusion therapy on motion perception deficits in amblyopia

et al. 2015

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“…This finding might be surprising at first glance because the fellow eye had acuity of at least 20/20, and because binocular acuity in 10 patients was comparable with fellow eye acuity (we did not collect binocular acuity in the other 8 patients because this was not part of our original protocol). However, despite normal acuity, deficits in the fellow eye have been well-documented in people with amblyopia, including second-order spatial loss, 35,36 impaired motion processing, 37,38 deficient contour integration, 39,40 and impaired perception of images of natural scenes. 41 It has been hypothesized that these higher-order deficits exist because second-order neurons are binocular and they require normal binocular input during development.…”

Section: Eye-hand Coordination During the Planning Stage Of Reachingmentioning

confidence: 99%

Effects of Anisometropic Amblyopia on Visuomotor Behavior, III: Temporal Eye-Hand Coordination during Reaching

Niechwiej-Szwedo

Goltz

Chandrakumar

et al. 2011

Invest. Ophthalmol. Vis. Sci.

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This is the first study to show that patients with anisometropic amblyopia modified the temporal dynamics of eye-hand coordination during visually-guided reaching. They extended the planning and execution intervals after target fixation and increased the frequency of secondary, reach-related saccades. These may represent visuomotor strategies to compensate for the spatiotemporal visual deficits to achieve good reaching accuracy and precision.

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“…23 Deficits on tasks that involve higher-order attentional components, including underestimation in a visual object enumeration task, 24 prolonged attentional blink, 25 and decreased accuracy when tracking single or multiple objects, 26 are also evident in amblyopic patients. In addition, the fellow eye in amblyopic patients demon-strates smaller deficits in contrast sensitivity, 2 7 Vernier acuity/positional uncertainty, [28][29][30] contour detection or detection of second-order image characteristics, 19,31,32 and detection of motiondefined form 33,34 exist concurrently with deficits in the amblyopic eye.…”

mentioning

confidence: 99%

Deficits in Perception of Images of Real-World Scenes in Patients With a History of Amblyopia

Mirabella

Hay²,

Wong³

2011

Arch Ophthalmol

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To investigate the perception of images of real-world scenes in patients with amblyopia and to compare their performance with that of visually normal participants by viewing conditions (monocular vs binocular) and by treatment outcomes (successfully vs unsuccessfully treated vs normal eyes). Methods: Thirty-nine healthy and 26 amblyopic individuals who had undergone previous amblyopia treatment were recruited to perform a match-to-sample task that used images of real-world scenes. Rates of correct, incorrect, and no responses and mean reaction time were recorded. Results: Performance during monocular viewing showed that the mean correct response rate was 59% in the amblyopic eyes, 62% in the fellow eyes, and 67% in the normal eyes (P=.008). During binocular viewing, the correct response rate remained reduced at 58% in amblyopic patients compared with 68% in participants with normal vision (P = .03). Performance by treatment outcomes showed that the mean correct response rate was 59% in the unsuccessfully treated group, 64% in the successfully treated group, and 67% in the normal group (P=.002). There was no difference in performance among amblyopia subtypes. Conclusions: Real-world scene perception is impaired in amblyopia, with the poorest performance during amblyopic monocular and binocular viewing. Despite successful treatment of the amblyopic eye to normal acuity levels, perception of images in real-world scenes remains deficient in patients with a history of amblyopia.

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Recovery of Contour Integration in Relation to LogMAR Visual Acuity during Treatment of Amblyopia in Children

Abstract: Refractive correction alone or in combination with occlusion therapy produces a normalization of contour-integration thresholds in amblyopia that is more rapid and complete than that achieved for visual acuity.

Cited by 15 publications

References 33 publications

The effect of occlusion therapy on motion perception deficits in amblyopia

The effect of occlusion therapy on motion perception deficits in amblyopia

Effects of Anisometropic Amblyopia on Visuomotor Behavior, III: Temporal Eye-Hand Coordination during Reaching

Deficits in Perception of Images of Real-World Scenes in Patients With a History of Amblyopia

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