Recovery of corticosteroid-induced changes in contractile properties and morphology of rat diaphragm.

Dekhuijzen, P.N.R.; Gayan‐Ramirez, Ghislaine; Bisschop, A; Bock, Martin de; Dom, René; Decramer, Marc

doi:10.1164/ajrccm.153.2.8564131

Am J Respir Crit Care Med

1996

DOI: 10.1164/ajrccm.153.2.8564131

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Recovery of corticosteroid-induced changes in contractile properties and morphology of rat diaphragm.

P.N.R. Dekhuijzen¹,

Ghislaine Gayan‐Ramirez²,

A Bisschop³

et al.

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Cited by 7 publications

(2 citation statements)

References 30 publications

(31 reference statements)

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“…This concept is supported by the observation that recovery from acute steroid myopathy, caused by shorttime high-dose steroid administration, appears to take several months [15]. Such a prolonged recovery period was also shown in a recent animal study [16].…”

mentioning

confidence: 58%

Effects of different treatment regimens of methylprednisolone on rat diaphragm contractility, immunohistochemistry and biochemistry

Balkom¹,

Heijden²,

Moerkerk³

et al. 1996

Eur Respir J

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confidence: 58%

Effects of different treatment regimens of methylprednisolone on rat diaphragm contractility, immunohistochemistry and biochemistry

Balkom¹,

Heijden²,

Moerkerk³

et al. 1996

Eur Respir J

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“…In animal models, recovery of steroid-induced fiber atrophy may be incomplete or markedly delayed. For example, Dekhuijzen and colleagues (19) reported type IIx/b fiber atrophy in the diaphragm and gastrocnemius muscles of the rat 2 mo after cessation of triamcinolone therapy.…”

mentioning

confidence: 99%

Insulin-like growth factor I prevents corticosteroid-induced diaphragm muscle atrophy in emphysematous hamsters

Fournier

Huang

et al. 2003

American Journal of Physiology-Regulatory, Integrative and Comp

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The aim of this study was to evaluate whether recombinant human insulin-like growth factor I (rhIGF-I) could attenuate or prevent diaphragm (DIA) fiber atrophy with corticosteroid (CS) administration to emphysematous (EMP) hamsters. DIA muscle IGF-I responses to CS administration with and without exogenous rhIGF-I administration were evaluated. Three groups were studied: 1) EMP; 2) EMP + triamcinolone (T; 0.4 mg.kg-1.day-1 im); and 3) EMP + T + IGF-I (600 microg/day by constant infusion). After 4 wk, the DIA was analyzed histochemically and biochemically (IGF-I mRNA levels by RT-PCR and endogenous and exogenous IGF-I peptide levels immunochemically). Body weights of EMP-T progressively decreased, while those of EMP and EMP-T-IGF-I remained stable despite similarly reduced food intake in both T groups. DIA weight was reduced with T but preserved with rhIGF-I infusion. DIA fiber proportions were similar among the groups. The cross-sectional areas of types I, IIa, and IIx fibers were reduced (17 to 31%) with T administration but unchanged with rhIGF-I infusion. DIA IGF-I mRNA levels were similar across all groups. By contrast, the endogenous DIA IGF-I levels were reduced (41%) in the EMP-T-IGF-I animals. Total DIA IGF-I levels (endogenous + exogenous) were still significantly reduced. IGF-I immunoreactivity confirmed this reduction in all DIA fibers. We conclude that DIA fiber atrophy with T was completely prevented by exogenous rhIGF-I administration. This effect was likely mediated by the pharmacological influences of exogenously administered rhIGF-I. We speculate that this results from increased bioavailability of free IGF-I to react with muscle receptors. Reduced endogenous IGF-I levels in the DIA likely reflect a negative-feedback influence. These results may have important clinical implications for treatment options to offset the adverse effects of CS on the respiratory muscles in patients with chronic lung disorders.

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Myosin heavy chain expression and muscle adaptation to chronic oral breathing in rat

Gelhaye

Martrette

Legrand-Frossi

et al. 2006

Respiratory Physiology & Neurobiology

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Recovery of corticosteroid-induced changes in contractile properties and morphology of rat diaphragm.

Cited by 7 publications

References 30 publications

Effects of different treatment regimens of methylprednisolone on rat diaphragm contractility, immunohistochemistry and biochemistry

Effects of different treatment regimens of methylprednisolone on rat diaphragm contractility, immunohistochemistry and biochemistry

Insulin-like growth factor I prevents corticosteroid-induced diaphragm muscle atrophy in emphysematous hamsters

Myosin heavy chain expression and muscle adaptation to chronic oral breathing in rat

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