Recovery of Four COVID-19 Patients via Ozonated Autohemotherapy

Abstract

We report a case series of ozonated autohemotherapy of four COVID-19 patients, classified as critically ill (1 patient), severe (1 patient), and moderate (2 patients). Each ozonated autohemotherapy treatment was performed at a concentration of 40 μg/ml of ozone per 100 ml of blood. The number of treatments varied from 1 to 9 depending on the disease severity. All 4 patients, including 1 critically ill patient with severe acute respiratory distress syndrome (ARDS) and life-threatening refractory hypoxemia, recovered uneventfully and were discharged from the hospital after viral clearance. The younger sibling of the critically ill patient was also diagnosed with COVID-19 and developed ARDS with hypoxemia, who received mechanical ventilation through an endotracheal tube and extracorporeal membrane oxygenation (ECMO) support. The overall medical cost for 18 days spent in the intensive care unit (ICU) and 56 days of hospitalization was $139,935 USD. On the other hand, our critically ill patient underwent 9 ozonated autohemotherapy treatments and spent 10 days in the ICU and was discharged on hospital day 30; his hospitalization cost amounted to $15,466.50 USD. This case series suggests that ozonated autohemotherapy may be an alternative noninvasive medical treatment for COVID-19 patients.

Ozone as an adjuvant therapy for COVID-19: A systematic review and meta-analysis

“…The quality assessment of case-control studies utilizing the NOS critical appraisal checklist resulted in three high-quality [18] , [19] , [20] and one medium-quality study [21] (Table S4) . Moreover, the quality of the case series was assessed using JBI and summarized in Supplementary Material s [27] , [28] , [29] , [30] (Table S5-S6) . Overall, none of the included studies had a low quality.…”

“…Thirteen studies were finally included, with a total of 241 COVID-19 patients belonging to the ozone as an adjuvant therapy group and 157 patients belonging to the standard therapy only as of the control group, respectively. In this review, the majority were observational studies (4 case-control studies, and 4 case-series) conducted in Spain [19] , [20] , [29] , Italy [18] , [28] , Turkey [21] , Egypt [27] , and China [30] . In addition, there is one clinical trial from India [22] , and four RCTs conducted in Italy [23] , [24] , India [25] and Turkey [26] .…”

SARS-CoV-2 Infection and Lung Regeneration

“…Some COVID-19 patients may require intubation and mechanical ventilation to relieve hypoxia symptoms ( 163 ). Trioxy therapy, known as trioxy autohemotherapy or immunotrioxy transfusion therapy, is a raised and tested COVID-19 treatment because of its potential capacity to stimulate the innate immune system ( 164 ).…”

Oxidation and “Unconventional” Approaches to Infection

“…Virions can be inactivated by ozone/ozonides while retaining their immunogenicity, quickening infection resolution and enhancing natural resistance. Outstanding clinical effectiveness of ozone therapy has been reported in meetings of ozone doctors sharing clinical work worldwide and in clinical case series of Ebola ( Rowen et al, 2016 ) and coronavirus ( Wu et al, 2020 ; Franzini et al, 2020 ).…”